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Literature summary for 3.4.11.18 extracted from

  • Chen, X.; Xie, S.; Bhat, S.; Kumar, N.; Shapiro, T.A.; Liu, J.O.
    Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo (2009), Chem. Biol., 16, 193-202.
    View publication on PubMed
Search for more literature for 3.4.11.18

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21, Saccharomyces cerevisiae strain INVSc1, and insect cells, none of the recombinant forms of MetAP2 exhibits enzymatic activity Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
fumagillin
-
 Plasmodium falciparum
fumarranol
-
 Plasmodium falciparum
TNP-470
-
 Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 MetAP2 overexpressed in Escherichia coli has an apparent molecular weight of 72000Da Plasmodium falciparum
90000
-
 MetAP2 overexpressed in Saccharomyces cerevisiae is approximately 90000 Da Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Met-L-Pro-p-nitroanilide + H2O
-
 Plasmodium falciparum L-Met + L-Pro-p-nitroanilide
-
 ?

Synonyms

Synonyms Comment Organism
MetAP2
-
 Plasmodium falciparum
methionine aminopeptidase 2
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
 in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C Plasmodium falciparum fumarranol
0.116
-
 in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C Plasmodium falciparum TNP-470