Literature summary for 3.4.11.18 extracted from

Xie, S.X.; Huang, W.J.; Ma, Z.Q.; Huang, M.; Hanzlik, R.P.; Ye, Q.Z.
Structural analysis of metalloform-selective inhibition of methionine aminopeptidase (2006), Acta Crystallogr. Sect. D, 62, 425-432.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitors, hanging drop vapour diffusion method, with 10-15% PEG20000, 0.1 M MES pH 6.5 and 2 mM MnCl2, or 33% PEG 3350, 0.1 M Bis-Tris pH 6.5, 0.2 M NH4OAc and 1.2 mM CoCl2	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
5-(2,5-dichlorophenyl)furan-2-carboxylic acid	potent and selective inhibitor	Escherichia coli
5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid	potent and selective inhibitor	Escherichia coli
N-cyclopentyl-N-(thiazol-2-yl)oxalamide	potent and selective inhibitor	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Met-peptide + H2O	Escherichia coli	-	Met + peptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AE18	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Met-peptide + H2O	-	Escherichia coli	Met + peptide	-	?

Synonyms

Synonyms	Comment	Organism
MetAP	-	Escherichia coli
methionine aminopeptidase	-	Escherichia coli

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Release 2023.1 (January 2023)