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Literature summary for 3.4.11.14 extracted from

  • Menzies, F.M.; Hourez, R.; Imarisio, S.; Raspe, M.; Sadiq, O.; Chandraratna, D.; OKane, C.; Rock, K.L.; Reits, E.; Goldberg, A.L.; Rubinsztein, D.C.
    Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy (2010), Hum. Mol. Genet., 19, 4573-4586.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.14

Cloned(Commentary)

Cloned (Comment) Organism
GFP fusion protein expressed in muscles of adult CD1 male mice and Drosophila Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
 Homo sapiens
PAQ-22
-
 Homo sapiens
puromycin
-
 Homo sapiens
puromycin aminonucleoside
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-4-methyl-coumaryl-7-amide + H2O
-
 Homo sapiens Ala + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
puromycin-sensitive aminopeptidase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00007
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens bestatin
0.00008
-
 non-competitive, pH not specified in the publication, temperature not specified in the publication Homo sapiens PAQ-22
0.0006
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens puromycin
0.0025
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens puromycin aminonucleoside

General Information

General Information Comment Organism
malfunction decrease in activity increases the aggregation and toxicity of expanded huntingtin exon 1, overexpression reduces aggregates and toxicity of mutant huntingtin exon 1 Homo sapiens
physiological function suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo, decreases aggregate number in cellular models of neurodegenerative diseases, enhances macroautophagy Homo sapiens