Literature summary for 3.4.11.1 extracted from

Fang, C.; Zhang, J.; Yang, H.; Peng, L.; Wang, K.; Wang, Y.; Zhao, X.; Liu, H.; Dou, C.; Shi, L.; Zhao, C.; Liang, S.; Li, D.; Wang, X.
Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression (2019), J. Cell. Biochem., 120, 3611-3620 .

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Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression and knockdown of the enzyme in breast cancer cells indicate that LAP3 can promote metastasis. A lentiviral vector is introduced to overexpression or knockdown LAP3 in MDA-MB-231 and MCF-7 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
bestatin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	immunohistochemistry analysis of expression levels of LAP3 in breast cancer tissues. Expression of LAP3 in 105 cases of breast cancer is analyzed. The expression rate of LAP3 differs in various pathological histological grades, phenotypes, overview	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
lap3	-	Homo sapiens
leucine aminopeptidase 3	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	bestatin and knockdown of LAP3 upregulate phosphorylation of Hsp27 and downregulate expression of fascin. Phosphorylation of Akt and expression of matrix metalloproteinase-2/9 can also be downregulated. LAP3 overexpression showed the opposite results	Homo sapiens
physiological function	overexpression of leucine aminopeptidase 3 (LAP3) is involved in proliferation, migration, and invasion of several tumor cells and plays a crucial role in tumor metastasis, role of LAP3 in the regulation of cancer cell migration and invasion, overview. High LAP3 expression is correlated with the grade of malignancy, phenotypes, overview. LAP3 promotes fascin expression through the p38-Hsp27-NF-kappaB signaling pathway	Homo sapiens

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Release 2023.1 (January 2023)