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Literature summary for 3.4.11.1 extracted from

  • Wu, H.; Jiang, W.; Li, B.; Yang, H.; Zhao, X.; Zhang, H.; Wang, S.; Peng, L.; Wang, L.; Wang, X.; Dai, G.; Fang, C.
    A new method to evaluate the enzyme-suppressing activity of a leucine aminopeptidase 3 inhibitor (2019), Drug Discov. Ther., 13, 17-21 .
    View publication on PubMed
Search for more literature for 3.4.11.1

Cloned(Commentary)

Cloned (Comment) Organism
a lentivirus is used to induce K-562 cells to overexpress LAP3 (K562-LAP3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information method development for usage of human leucine aminopeptidase to evaluate the suppression of enzyme activity by an LAP3 inhibitor Homo sapiens
ubenimex suppresses the enzyme activity in vivo in K562-LAP3 cells, detection method development and evaluation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ leucine aminopeptidases (LAPs) are zinc-containing metalloproteinases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P28838
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BV-2 cell
-
 Homo sapiens
-
EAhy 926 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
PLC/PRF/5 cell
-
 Homo sapiens
-
RMC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine 4-nitroanilide + H2O
-
 Homo sapiens L-leucine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
cytosol aminopeptidase UniProt Homo sapiens
lap3
-
 Homo sapiens
leucine aminopeptidase 3
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
evolution leucine aminopeptidases (LAPs) are members of the aminopeptidase M1/M17 family Homo sapiens
physiological function expression of leucine aminopeptidase 3 (LAP3) is associated with the prognosis for and malignant transformation of many types of tumors Homo sapiens