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Literature summary for 3.4.11.1 extracted from

  • Rout, S.; Mahapatra, R.K.
    In silico screening of novel inhibitors of M17 leucine amino peptidase (LAP) of Plasmodium vivax as therapeutic candidate (2016), Biomed. Pharmacother., 82, 192-201 .
    View publication on PubMed
Search for more literature for 3.4.11.1

Inhibitors

Inhibitors Comment Organism Structure
(4S)-4-amino-4,5-dihydro-2H-pyrazolo[3,4-f]quinoline-3-carboxylic acid
-
 Plasmodium vivax
(4S)-4-amino-7-methyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinazoline-3-carboxylic acid
-
 Plasmodium vivax
(4S)-4-amino-8-ethyl-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxylic acid
-
 Plasmodium vivax
(4S)-4-amino-9-methyl-4,5-dihydro-2H-pyrazolo[3,4-f]quinoline-3-carboxylic acid
-
 Plasmodium vivax
(4S)-4-amino-9-methyl-4,5-dihydro[1,2]oxazolo[5,4-f]quinoline-3-carboxylic acid
-
 Plasmodium vivax
2-[(3-azaniumyl-2-hydroxy-4-phenylbutanoyl)amino]-4-methylpentanoate the binding mode of the inhibitor is confirmed by a molecular dynamics (MD) simulation study, evaluation of the drug likeness Plasmodium vivax
4-amino-6,7-dimethyl-2,4,5,6-tetrahydropyrrolo[2,3-g]indazole-3-carboxylic acid
-
 Plasmodium vivax
benzyl N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate
-
 Plasmodium vivax
bestatin [(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]-L-leucine, a potent and slow binding inhibitor Plasmodium vivax
additional information de novo drug design, and structure-based virtual screening of the ZINC database and molecular docking study Plasmodium vivax
N-[(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-D-leucine
-
 Plasmodium vivax

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Plasmodium vivax 5829
-

Organism

Organism UniProt Comment Textmining
Plasmodium vivax A5K3U9
-
-
Plasmodium vivax Salvador I A5K3U9
-
-

Subunits

Subunits Comment Organism
homodimer
-
 Plasmodium vivax
More the modeled protein structure has an N-terminal domain consisting of three alpha-helices and six beta-sheets, a helical region linking the two domains, C-terminal catalytic domain comprising ten alpha-helices and seven beta-sheets Plasmodium vivax

Synonyms

Synonyms Comment Organism
M17 LAP
-
 Plasmodium vivax
M17 leucine amino peptidase
-
 Plasmodium vivax
PVX_118180
-
 Plasmodium vivax

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000025
-
 bestatin pH and temperature not specified in the publication Plasmodium vivax

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01487
-
 pH and temperature not specified in the publication Plasmodium vivax bestatin

General Information

General Information Comment Organism
additional information structure homology modelling of Plasmodium vivax LAP using the crystal structure of Plasmodium falciparum LAP, PDB ID 3KQX, as template, overview Plasmodium vivax
physiological function M17 leucine amino peptidase (M17 LAP) plays an important role in the hydrolysis of amino acids essential for growth and development of Plasmodium vivax Plasmodium vivax