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Literature summary for 3.4.11.1 extracted from

  • Deng, C.; Sun, J.; Li, X.; Wang, L.; Hu, X.; Wang, X.; Chen, W.; Lv, X.; Liang, C.; Li, W.; Huang, Y.; Li, R.; Wu, Z.; Yu, X.; Xu, J.
    Molecular identification and characterization of leucine aminopeptidase 2, an excretory-secretory product of Clonorchis sinensis (2012), Mol. Biol. Rep., 39, 9817-9826.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant CsLAP2 is expressed and purified in Escherichia coli BL21 Clonorchis sinensis

Inhibitors

Inhibitors Comment Organism Structure
bestatin
-
Clonorchis sinensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0182
-
L-Leu-7-amido-4-methylcoumarin pH 7.5, 37°, Vmax: 10.7 microM/min Clonorchis sinensis

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ strong inhibitory effect Clonorchis sinensis
Mg2+ slight activation Clonorchis sinensis
Mn2+ slight activation Clonorchis sinensis
Zn2+ strong inhibitory effect Clonorchis sinensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
59800
-
SDS-PAGE Clonorchis sinensis

Organism

Organism UniProt Comment Textmining
Clonorchis sinensis C6FWG9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
Clonorchis sinensis
-
intestine
-
Clonorchis sinensis
-
metacercaria CsLAP2 is located at the tegument and excretory vesicle of metacercaria as shown by histochemical analysis Clonorchis sinensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-7-amido-4-methylcoumarin + H2O
-
Clonorchis sinensis L-Leu + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
CsLAP2
-
Clonorchis sinensis
LAP2
-
Clonorchis sinensis
leucine aminopeptidase 2
-
Clonorchis sinensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
assay at Clonorchis sinensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Clonorchis sinensis

Expression

Organism Comment Expression
Clonorchis sinensis expression can be detected at the stages of the adult worm, metacercaria, excysted metacercaria and egg. CsLAP2 shows a higher expression level at the stage of excysted metacercaria than the adult worm (3.90fold), metacercaria (4.60fold) and egg (4.59fold) up