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Literature summary for 3.4.11.1 extracted from

  • Shin, E.; Seifert, U.; Urban, S.; Truong, K.; Feinstone, S.M.; Rice, C.M.; Kloetzel, P.; Rehermann, B.
    Proteasome activator and antigen-processing aminopeptidases are regulated by virus-induced type I interferon in the hepatitis C virus-infected liver (2008), J. Interferon Cytokine Res., 27, 985-990.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Pan troglodytes
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Pan troglodytes
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with acute HCV infection
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Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell IFN-alpha, IFN-beta, or IFN-gamma induce the expression of LAP at the mRNA and protein level. Transfection with the synthetic dsRNA poly(I-C) results in an increase in LAP mRNA levels. Transfection of Huh-7 cells with HCV RNA increases mRNA levels of LAP Homo sapiens
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liver hepatitis C virus-infected. The enzyme is regulated by virus-induced type I interferon in the hepatitis C virus-infected liver Pan troglodytes
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liver intrahepatic LAP mRNA levels started to increase 2 weeks after infection and peak 5-8 weeks after HCV infection Pan troglodytes
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