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Literature summary for 3.3.2.9 extracted from
- Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical (2008), Pest Manag. Sci., 64, 594-609.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,1,1-trichloro-2,3-epoxypropane | - |
Homo sapiens |  |
| 1,1,1-trichloro-2,3-epoxypropane | - |
Mus musculus | |
| Cyclohexene oxide | - |
Homo sapiens | |
| Cyclohexene oxide | - |
Mus musculus | |
| elaidamide | most potent inhibitor, has a mix of competitive and non-competitive inhibition kinetics | Homo sapiens | |
| elaidamide | most potent inhibitor, has a mix of competitive and non-competitive inhibition kinetics | Mus musculus | |
| progabide | low micromolar inhibitor | Homo sapiens | |
| progabide | low micromolar inhibitor | Mus musculus | |
| valpromide | low micromolar inhibitor | Homo sapiens | |
| valpromide | low micromolar inhibitor | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | mEH is also associated with the nuclear and plasma membranes | Mus musculus | 16020 | - |
| membrane | mEH is also associated with the nuclear and plasma membranes | Homo sapiens | 16020 | - |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| smooth endoplasmic reticulum | mEH is mostly found attached to the smooth endoplasmic reticulum | Mus musculus | 5790 | - |
| smooth endoplasmic reticulum | mEH is mostly found attached to the smooth endoplasmic reticulum | Homo sapiens | 5790 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
- |
Mus musculus |
| 50000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | mEH mediates the transport of bile acid in the liver | ? | - |
? | |
| additional information | Homo sapiens | mEH mediates the transport of bile acid in the liver | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | mEH is particularly concentrated in the adrenal gland | Mus musculus | - |
| adrenal gland | mEH is particularly concentrated in the adrenal gland | Homo sapiens | - |
| heart | mEH is particularly concentrated in the heart | Mus musculus | - |
| heart | mEH is particularly concentrated in the heart | Homo sapiens | - |
| liver | mEH is particularly concentrated in the liver | Mus musculus | - |
| liver | mEH is particularly concentrated in the liver | Homo sapiens | - |
| lung | mEH is particularly concentrated in the lung | Mus musculus | - |
| lung | mEH is particularly concentrated in the lung | Homo sapiens | - |
| ovarian follicle | - |
Mus musculus | - |
| ovary | - |
Mus musculus | - |
| testis | mEH is particularly concentrated in the testis | Mus musculus | - |
| testis | mEH is particularly concentrated in the testis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O | excellent and selective substrate for mEH | Mus musculus | 1,2,3,4,9,9-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene-6,7-diol | - |
? | |
| 1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O | excellent and selective substrate for mEH | Homo sapiens | 1,2,3,4,9,9-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene-6,7-diol | - |
? | |
| 16alpha,17alpha-epoxyandrosten-3-one + H2O | endogenous substrate of mEH | Mus musculus | ? | - |
? | |
| 16alpha,17alpha-epoxyandrosten-3-one + H2O | endogenous substrate of mEH | Homo sapiens | ? | - |
? | |
| cis-stilbene oxide + H2O | - |
Mus musculus | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| cis-stilbene oxide + H2O | - |
Homo sapiens | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
| additional information | mEH mediates the transport of bile acid in the liver | Mus musculus | ? | - |
? | |
| additional information | mEH mediates the transport of bile acid in the liver | Homo sapiens | ? | - |
? | |
| additional information | mEH prefers mono- and cis-1,2-disubstituted epoxides, while gem-di-, trans-di-, tri- and tetrasubstituted epoxides are low-turnover substrates or inhibitors | Mus musculus | ? | - |
? | |
| additional information | mEH prefers mono- and cis-1,2-disubstituted epoxides, while gem-di-, trans-di-, tri- and tetrasubstituted epoxides are low-turnover substrates or inhibitors | Homo sapiens | ? | - |
? | |
| trans-stilbene oxide + H2O | - |
Mus musculus | 1,2-diphenylethane-1,2-diol | - |
? | |
| trans-stilbene oxide + H2O | - |
Homo sapiens | 1,2-diphenylethane-1,2-diol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mEH | - |
Mus musculus |
| mEH | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00007 | - |
elaidamide | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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