Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.3.2.7 extracted from

  • An, J.; Song, Y.; Kim, K.; Ko, Y.; Yoon, D.; Oh, D.
    Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes (2018), Nat. Commun., 9, 128-136 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.7

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepoxilin A3 + H2O Homo sapiens
-
 trioxilin A3
-
 ?
hepoxilin B3 + H2O Homo sapiens
-
 trioxilin B3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepoxilin A3 + H2O
-
 Homo sapiens trioxilin A3
-
 ?
hepoxilin B3 + H2O
-
 Homo sapiens trioxilin B3
-
 ?
additional information hydrolysis of the epoxy group in HXA3 and HXB3, respectively, by HX epoxide hydrolase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HX epoxide hydrolase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells. Hepoxilin epoxide hydrolase converts hepoxilins into trioxilins through hydrolysis of the epoxy group Homo sapiens