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Literature summary for 3.3.2.6 extracted from

  • Zhao, S.; Yao, K.; Li, D.; Liu, K.; Jin, G.; Yan, M.; Wu, Q.; Chen, H.; Shin, S.H.; Bai, R.; Wang, G.; Bode, A.M.; Dong, Z.; Guo, Z.; Dong, Z.
    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer (2019), EBioMedicine, 44, 361-374 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Application

Application Comment Organism
diagnostics LTB4 can serve as a biomarker for evaluating bestatin efficacy in colorectal cancer and the antitumor effects of bestatin through its targeting of LTA4H Homo sapiens
medicine LTB4 can serve as a biomarker for evaluating bestatin efficacy in colorectal cancer and the antitumor effects of bestatin through its targeting of LTA4H Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR expression analysis Homo sapiens
quantitative real-time PCR expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
bestatin significantly inhibits LTB4 production, samples from13 CRC patients show a significant decrease in LTB4, the LTA4H signaling pathway, and Ki-67 in the bestatin-treated group compared with the untreated group Homo sapiens
bestatin significantly inhibit LTB4 production, bestatin effectively inhibits LTB4 synthesis and tumorigenesis in the ApcMin/+ and CRC patient-derived xenograft mouse model Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?
leukotriene A4 + H2O Mus musculus
-
 leukotriene B4
-
 ?
leukotriene A4 + H2O Mus musculus C57BL/6J
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09960
-
-
Mus musculus P24527
-
-
Mus musculus C57BL/6J P24527
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon LTA4H and BLT1 are highly expressed in colitis and correlate with colon adenocarcinoma Homo sapiens
-
colorectal cancer cell
-
 Mus musculus
-
colorectal cancer cell LTA4H and BLT1 are overexpressed in colitis and correlate with colon adenocarcinoma, phenotypes, overview Homo sapiens
-
epithelial cell colonic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
leukotriene A4 + H2O
-
 Mus musculus leukotriene B4
-
 ?
leukotriene A4 + H2O
-
 Mus musculus C57BL/6J leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
LTA4H
-
 Homo sapiens
LTA4H
-
 Mus musculus

General Information

General Information Comment Organism
physiological function in the eicosanoid metabolic processes, leukotriene A4 hydrolase (LTA4H) is an epoxide hydrolase that catalyzes conversion of the unstable allelic epoxide leukotriene A4 (LTA4) to leukotriene B4 (LTB4), which is known to have classical biological functions including chemotaxis, endothelial adherence, and activation of leukocytes. It exerts its actions through a transmembrane protein receptor, LTB4 receptor type 1 (BLT1). The leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and leukotriene B4 receptor type 1 (BLT1) are also associated with CRC survival probability Mus musculus
physiological function in the eicosanoid metabolic processes, leukotriene A4 hydrolase (LTA4H) is an epoxide hydrolase that catalyzes conversion of the unstable allelic epoxide leukotriene A4 (LTA4) to leukotriene B4 (LTB4), which is known to have classical biological functions including chemotaxis, endothelial adherence, and activation of leukocytes. It exerts its actions through a transmembrane protein receptor, LTB4 receptor type 1 (BLT1). The leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and leukotriene B4 receptor type 1 (BLT1) are also associated with CRC survival probability. High expression of LTA4H and BLT1 negatively correlate with CRC patient survival probability Homo sapiens