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Literature summary for 3.3.2.6 extracted from

  • Stsiapanava, A.; Olsson, U.; Wan, M.; Kleinschmidt, T.; Rutishauser, D.; Zubarev, R.A.; Samuelsson, B.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
    Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor (2014), Proc. Natl. Acad. Sci. USA, 111, 4227-4232.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM101 cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
mutant E296Q in complex with N-(4-oxo-4-pyrrolidinyl-butanoyl)-L-proline, liquid/liquid diffusion method, using 22-30% (w/v) PEG 8000, 100 mM NaAc, 100 mM imidazole buffer (pH 6.5-7.0), and 5 mM YbCl3 Homo sapiens

Protein Variants

Protein Variants Comment Organism
E296Q inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(4-benzylphenyl)thiazol-2-amine
-
 Homo sapiens
SC-57461A i.e. N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-L-alanine Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09960
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
 Homo sapiens L-Ala + 4-nitroaniline
-
 ?
L-Pro-Gly-L-Pro + H2O
-
 Homo sapiens ?
-
 ?
L-Val-4-nitroanilide + H2O
-
 Homo sapiens L-Val + 4-nitroaniline
-
 ?
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Homo sapiens
leukotriene A4 hydrolase/aminopeptidase
-
 Homo sapiens
LTA4H
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
 4-(4-benzylphenyl)thiazol-2-amine at pH 7.8 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 at pH 7.8 and 37°C Homo sapiens 4-(4-benzylphenyl)thiazol-2-amine