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Literature summary for 3.3.2.6 extracted from

  • Black, A.T.; Joseph, L.B.; Casillas, R.P.; Heck, D.E.; Gerecke, D.R.; Sinko, P.J.; Laskin, D.L.; Laskin, J.D.
    Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide (2010), Toxicol. Appl. Pharmacol., 245, 352-360.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Mus musculus
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Mus musculus
-
PAM212 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Mus musculus leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
leukotriene A4 hydrolase
-
 Mus musculus
LTA4 hydrolase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme expression is upregulated in keratinocytes by 2-chloroethyl ethyl sulfide via p38MAP kinase signaling pathway, inhibition of p38 MAP kinase suppresses CEES-induced expression of LTA4 hydrolase, overview up

General Information

General Information Comment Organism
metabolism LTA4H in reactive oxygen species detoxification pathways and eicosanoid biosynthetic pathways, overview Mus musculus