Literature summary for 3.3.2.6 extracted from

Jeong, C.H.; Bode, A.M.; Pugliese, A.; Cho, Y.Y.; Kim, H.G.; Shim, J.H.; Jeon, Y.J.; Li, H.; Jiang, H.; Dong, Z.
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase (2009), Cancer Res., 69, 5584-5591.

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Inhibitors

Inhibitors	Comment	Organism	Structure
[6]-gingerol	from ginger, [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA4H activity in HCT116 colorectal cancer cells, overview. [6]-Gingerol specifically binds with LTA4H in vitro and ex vivo	Homo sapiens
[6]-gingerol	from ginger, [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA4H activity in mice, overview. [6]-Gingerol specifically binds with LTA4H in vitro and ex vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09960	-	-
Mus musculus	-	NIH Swiss nude mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Mus musculus	-
colorectal cancer cell	-	Homo sapiens	-
HCT-116 cell	high expression level	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
leukotriene A4 hydrolase	-	Mus musculus
leukotriene A4 hydrolase	-	Homo sapiens
LTA4H	-	Mus musculus
LTA4H	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	knockdown of LTA4H inhibits anchorage-independent growth of HCT116 colon cancer cells	down

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Release 2023.1 (January 2023)