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Literature summary for 3.3.2.6 extracted from

  • Arguello, M.; Paz, S.; Hernandez, E.; Corriveau-Bourque, C.; Fawaz, L.M.; Hiscott, J.; Lin, R.
    Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production (2006), J. Immunol., 176, 7051-7061.
    View publication on PubMed

Application

Application Comment Organism
medicine understanding the molecular alterations that influence primary effusion lymphoma development will aid in the identification of novel therapeutic targets, as well as potential risk factors for this desease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Homo sapiens
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(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BCBL-1 cell primary effusion lymphoma Homo sapiens
-
BJAB cell
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Homo sapiens
-
L-428 cell classical Hodgkins disease Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
-
Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
leukotriene-A4 hydrolase
-
Homo sapiens
LTA4H
-
Homo sapiens