Literature summary for 3.3.2.6 extracted from

Mueller, M.J.; Andberg, M.; Haeggstrom, J.Z.
Analysis of the molecular mechanism of substrate-mediated inactivation of leukotriene A4 hydrolase (1998), J. Biol. Chem., 273, 11570-11575.

Search for more literature for 3.3.2.6

Application

Application	Comment	Organism
medicine	the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E318A	the exposure of mutant enzyme to leukotriene A4, leukotriene methyl ester or leukotriene ethyl ester results in covalent modification of peptide K21 to the same extent as for wild-type enzyme	Homo sapiens
Y378F	mutant is only partially protected against inactivation by leukotriene methyl ester and leukotriene ethyl ester	Homo sapiens
Y378Q	mutant is only partially protected against inactivation by leukotriene methyl ester and leukotriene ethyl ester	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
leukotriene A4	comparison of inactivation of wild-type and mutant enzymes; suicide inactivation	Homo sapiens
leukotriene A4 ethyl ester	comparison of inactivation of wild-type and mutant enzymes	Homo sapiens
leukotriene A4 methyl ester	comparison of inactivation of wild-type and mutant enzymes	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zinc	zinc protein	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
leukotriene A4 + H2O	Homo sapiens	biosynthesis of leukotriene B4	leukotriene B4	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
leukotriene A4 + H2O	-	Homo sapiens	leukotriene B4	-	?
leukotriene A4 + H2O	biosynthesis of leukotriene B4	Homo sapiens	leukotriene B4	-	?

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Release 2023.1 (January 2023)