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Literature summary for 3.3.2.6 extracted from

  • Haeggström, J.; Bergman, T.; Jörnvall, H.; Radmark, O.
    Guinea-pig liver leukotriene A4 hydrolase. Purification, characterization and structural properties (1988), Eur. J. Biochem., 174, 717-724.
    View publication on PubMed
Search for more literature for 3.3.2.6

Application

Application Comment Organism
medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
 leukotriene A4 pH 8.0, 37°C Cavia porcellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000 46000 gel filtration Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8
-
-
 Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Cavia porcellus leukotriene B4
-
 ?

Subunits

Subunits Comment Organism
? x * 67000-71000, SDS-PAGE Cavia porcellus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
 assay at Cavia porcellus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Cavia porcellus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Cavia porcellus

pI Value

Organism Comment pI Value Maximum pI Value
Cavia porcellus chromatofocusing
-
 6.2