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Literature summary for 3.3.2.11 extracted from
- Cholesterol epoxide hydrolase and cancer (2012), Curr. Opin. Pharmacol., 12, 696-703.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxy-tamoxifen | - |
Homo sapiens |  |
| 6-ketocholestanol | - |
Homo sapiens | |
| 7-ketocholestanol | - |
Homo sapiens | |
| 7-ketocholesterol | - |
Homo sapiens | |
| alpha-linolenic acid | - |
Homo sapiens | |
| amiodarone | - |
Homo sapiens | |
| arachidonic acid | - |
Homo sapiens | |
| cholestane-3beta,5alpha,6beta-triol | - |
Homo sapiens | |
| clomiphene | - |
Homo sapiens | |
| docosahexaenoic acid | - |
Homo sapiens | |
| haloperidol | - |
Homo sapiens | |
| N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | - |
Homo sapiens | |
| oleic acid | - |
Homo sapiens | |
| raloxifene | - |
Homo sapiens | |
| SR31747A | - |
Homo sapiens | |
| tamoxifen | - |
Homo sapiens | |
| terbinafine | - |
Homo sapiens | |
| tesmilifene | - |
Homo sapiens | |
| trifluoroperazine | - |
Homo sapiens | |
| U-18666A | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | - |
5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
| 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | Homo sapiens | better substrate | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| intestinal epithelium | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | richest source tissue | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
| 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | better substrate | Homo sapiens | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| anti-estrogen binding site | cholesterol epoxide hydrolase is a heterooligomeric complex called the anti-estrogen binding site comprising 3beta-hydroxysterol-DELTA8-DELTA7-isomerase and 3beta-hydroxysterol-DELTA7-reductase | Homo sapiens |
| ChEH | - |
Homo sapiens |
| cholesterol epoxide hydrolase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000006 | - |
SR31747A | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000027 | - |
N-pyrrolidino-2-[4-(benzyl)-phenoxy]-ethanamine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000034 | - |
tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000036 | - |
raloxifene | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000062 | - |
tesmilifene | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00009 | - |
U-18666A | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000135 | - |
trifluoroperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000145 | - |
4-hydroxy-tamoxifen | pH and temperature not specified in the publication | Homo sapiens | |
| 0.000733 | - |
amiodarone | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0042 | - |
7-ketocholesterol | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0091 | - |
terbinafine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.0097 | - |
cholestane-3beta,5alpha,6beta-triol | pH and temperature not specified in the publication | Homo sapiens | |
| 0.012 | - |
docosahexaenoic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.018 | - |
haloperidol | pH and temperature not specified in the publication | Homo sapiens | |
| 0.024 | - |
arachidonic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.036 | - |
alpha-linolenic acid | pH and temperature not specified in the publication | Homo sapiens | |
| 0.054 | - |
oleic acid | pH and temperature not specified in the publication | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a potential role in cancer progression and resistance | Homo sapiens |
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