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Literature summary for 3.3.2.11 extracted from
- Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer (2013), Biochimie, 95, 622-631.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tamoxifen | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Rattus norvegicus | - |
5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
| 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | Rattus norvegicus | best substrate | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Rattus norvegicus | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
| 5,6beta-epoxy-5alpha-cholestan-3beta-ol + H2O | best substrate | Rattus norvegicus | 5alpha-cholestane-3beta,5alpha,6beta-triol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ChEH | - |
Rattus norvegicus |
| cholesterol-5,6-epoxide hydrolase | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | primary and secondary products of the enzyme's activity have tumor promoting and carcinogenic activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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