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show all sequences of 3.3.2.11

Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

de Medina, P.; Paillasse, M.R.; Segala, G.; Poirot, M.; Silvente-Poirot, S.; Proc. Natl. Acad. Sci. USA 107, 13520-13525 (2010)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
-
Rattus norvegicus
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone
-
Rattus norvegicus
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
-
Rattus norvegicus
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
-
Rattus norvegicus
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
-
Rattus norvegicus
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
-
Rattus norvegicus
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine
-
Rattus norvegicus
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone
-
Rattus norvegicus
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
-
Rattus norvegicus
2-(4-benzylphenoxy)-N,N-diethylethanamine
-
Rattus norvegicus
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
-
Rattus norvegicus
2-(diethylamino)ethyl 2,2-diphenylpentanoate
-
Rattus norvegicus
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
-
Rattus norvegicus
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one
-
Rattus norvegicus
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
-
Rattus norvegicus
4-(2-(4-benzylphenoxy)ethyl)morpholine
-
Rattus norvegicus
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
-
Rattus norvegicus
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
-
Rattus norvegicus
6-oxo-5-alpha-hydroxycholestanol
-
Rattus norvegicus
6-oxocholestanol
-
Rattus norvegicus
7-oxocholestanol
-
Rattus norvegicus
7-oxocholesterol
-
Rattus norvegicus
7alpha-hydroxycholesterol
-
Rattus norvegicus
7beta-hydroxycholesterol
-
Rattus norvegicus
AC-915
-
Rattus norvegicus
alpha-linolenic acid
-
Rattus norvegicus
amiodarone
-
Rattus norvegicus
arachidonic acid
-
Rattus norvegicus
cholestane-3beta,5alpha,6beta-triol
-
Rattus norvegicus
docosahexaenoic acid
-
Rattus norvegicus
ibogaine
-
Rattus norvegicus
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
-
Rattus norvegicus
oleic acid
-
Rattus norvegicus
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
-
Rattus norvegicus
rimcazole
-
Rattus norvegicus
tamoxifen
0.01 mM, competitive
Rattus norvegicus
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane
-
Rattus norvegicus
trifluoroperazine
-
Rattus norvegicus
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0074
-
5,6alpha-epoxy-5alpha-cholestan-3beta-ol
pH 7.4, 37C
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
706552
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
706552
Rattus norvegicus
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O
-
706552
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O
-
706552
Rattus norvegicus
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Rattus norvegicus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000006
-
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
pH 7.4, 37C
Rattus norvegicus
0.000009
-
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
pH 7.4, 37C
Rattus norvegicus
0.000018
-
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000027
-
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000027
-
4-(2-(4-benzylphenoxy)ethyl)morpholine
pH 7.4, 37C
Rattus norvegicus
0.000034
-
tamoxifen
pH 7.4, 37C
Rattus norvegicus
0.000035
-
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000036
-
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
pH 7.4, 37C
Rattus norvegicus
0.000039
-
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
pH 7.4, 37C
Rattus norvegicus
0.000057
-
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
pH 7.4, 37C
Rattus norvegicus
0.000062
-
2-(4-benzylphenoxy)-N,N-diethylethanamine
pH 7.4, 37C
Rattus norvegicus
0.000089
-
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
pH 7.4, 37C
Rattus norvegicus
0.00009
-
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one
pH 7.4, 37C
Rattus norvegicus
0.000099
-
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
pH 7.4, 37C
Rattus norvegicus
0.000135
-
trifluoroperazine
pH 7.4, 37C
Rattus norvegicus
0.000145
-
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
pH 7.4, 37C
Rattus norvegicus
0.000155
-
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
pH 7.4, 37C
Rattus norvegicus
0.000203
-
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
pH 7.4, 37C
Rattus norvegicus
0.000241
-
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone
pH 7.4, 37C
Rattus norvegicus
0.000649
-
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane
pH 7.4, 37C
Rattus norvegicus
0.000733
-
amiodarone
pH 7.4, 37C
Rattus norvegicus
0.000864
-
7-oxocholestanol
pH 7.4, 37C
Rattus norvegicus
0.000902
-
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone
pH 7.4, 37C
Rattus norvegicus
0.0019
-
2-(diethylamino)ethyl 2,2-diphenylpentanoate
pH 7.4, 37C
Rattus norvegicus
0.002
-
ibogaine
pH 7.4, 37C
Rattus norvegicus
0.0023
-
6-oxocholestanol
pH 7.4, 37C
Rattus norvegicus
0.0023
-
rimcazole
pH 7.4, 37C
Rattus norvegicus
0.0035
-
AC-915
pH 7.4, 37C
Rattus norvegicus
0.0042
-
7-oxocholesterol
pH 7.4, 37C
Rattus norvegicus
0.0061
-
7alpha-hydroxycholesterol
pH 7.4, 37C
Rattus norvegicus
0.0069
-
7beta-hydroxycholesterol
pH 7.4, 37C
Rattus norvegicus
0.0085
-
6-oxo-5-alpha-hydroxycholestanol
pH 7.4, 37C
Rattus norvegicus
0.0091
-
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
pH 7.4, 37C
Rattus norvegicus
0.0097
-
cholestane-3beta,5alpha,6beta-triol
pH 7.4, 37C
Rattus norvegicus
0.012
-
docosahexaenoic acid
pH 7.4, 37C
Rattus norvegicus
0.018
-
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
pH 7.4, 37C
Rattus norvegicus
0.024
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.0363
-
alpha-linolenic acid
pH 7.4, 37C
Rattus norvegicus
0.054
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
-
Rattus norvegicus
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone
-
Rattus norvegicus
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
-
Rattus norvegicus
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
-
Rattus norvegicus
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
-
Rattus norvegicus
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
-
Rattus norvegicus
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine
-
Rattus norvegicus
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone
-
Rattus norvegicus
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
-
Rattus norvegicus
2-(4-benzylphenoxy)-N,N-diethylethanamine
-
Rattus norvegicus
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
-
Rattus norvegicus
2-(diethylamino)ethyl 2,2-diphenylpentanoate
-
Rattus norvegicus
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
-
Rattus norvegicus
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one
-
Rattus norvegicus
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
-
Rattus norvegicus
4-(2-(4-benzylphenoxy)ethyl)morpholine
-
Rattus norvegicus
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
-
Rattus norvegicus
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
-
Rattus norvegicus
6-oxo-5-alpha-hydroxycholestanol
-
Rattus norvegicus
6-oxocholestanol
-
Rattus norvegicus
7-oxocholestanol
-
Rattus norvegicus
7-oxocholesterol
-
Rattus norvegicus
7alpha-hydroxycholesterol
-
Rattus norvegicus
7beta-hydroxycholesterol
-
Rattus norvegicus
AC-915
-
Rattus norvegicus
alpha-linolenic acid
-
Rattus norvegicus
amiodarone
-
Rattus norvegicus
arachidonic acid
-
Rattus norvegicus
cholestane-3beta,5alpha,6beta-triol
-
Rattus norvegicus
docosahexaenoic acid
-
Rattus norvegicus
ibogaine
-
Rattus norvegicus
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
-
Rattus norvegicus
oleic acid
-
Rattus norvegicus
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
-
Rattus norvegicus
rimcazole
-
Rattus norvegicus
tamoxifen
0.01 mM, competitive
Rattus norvegicus
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane
-
Rattus norvegicus
trifluoroperazine
-
Rattus norvegicus
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
-
Rattus norvegicus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000006
-
(E)-N-(4-(3-chloro-4-cyclohexylphenyl)but-3-enyl)-N-ethylcyclohexanamine
pH 7.4, 37C
Rattus norvegicus
0.000009
-
2-[4-[(Z)-2-chloro-1,2-di (phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
pH 7.4, 37C
Rattus norvegicus
0.000018
-
1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000027
-
1-(2-(4-benzylphenoxy)ethyl)-pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000027
-
4-(2-(4-benzylphenoxy)ethyl)morpholine
pH 7.4, 37C
Rattus norvegicus
0.000034
-
tamoxifen
pH 7.4, 37C
Rattus norvegicus
0.000035
-
1-(2-(4-(2-phenylpropan-2-yl) phenoxy)ethyl)pyrrolidine
pH 7.4, 37C
Rattus norvegicus
0.000036
-
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
pH 7.4, 37C
Rattus norvegicus
0.000039
-
2-(4-chlorophenyl)-1-(4-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl ethanol
pH 7.4, 37C
Rattus norvegicus
0.000057
-
4-(2-(4-(2-phenylpropan-2-yl)phenoxy)ethyl)morpholine
pH 7.4, 37C
Rattus norvegicus
0.000062
-
2-(4-benzylphenoxy)-N,N-diethylethanamine
pH 7.4, 37C
Rattus norvegicus
0.000089
-
(4-(6-(allyl (methyl)amino)hexyloxy)phenyl)(4-bromophenyl)methanone
pH 7.4, 37C
Rattus norvegicus
0.00009
-
3-beta-(2-(diethyl amino)ethoxy)androst-5-en-17-one
pH 7.4, 37C
Rattus norvegicus
0.000099
-
N-(3,4-dichlorophenethyl)-N-methyl-2-(pyrrolidin-1-yl)ethanemine
pH 7.4, 37C
Rattus norvegicus
0.000135
-
trifluoroperazine
pH 7.4, 37C
Rattus norvegicus
0.000145
-
4-[(Z)-1-[4-(2-dimethylaminoethyloxy)phenyl]-2-phenyl but-1-enyl]phenol
pH 7.4, 37C
Rattus norvegicus
0.000155
-
(11beta,17beta)-11-{4-[2-(Dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol
pH 7.4, 37C
Rattus norvegicus
0.000203
-
phenyl{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}methanone
pH 7.4, 37C
Rattus norvegicus
0.000241
-
(4-(2-morpholinoethoxy)phenyl)(phenyl)methanone
pH 7.4, 37C
Rattus norvegicus
0.000649
-
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane
pH 7.4, 37C
Rattus norvegicus
0.000733
-
amiodarone
pH 7.4, 37C
Rattus norvegicus
0.000864
-
7-oxocholestanol
pH 7.4, 37C
Rattus norvegicus
0.000902
-
1-(4-(2-morpholino ethoxy)phenyl)-2-phenylethanone
pH 7.4, 37C
Rattus norvegicus
0.0019
-
2-(diethylamino)ethyl 2,2-diphenylpentanoate
pH 7.4, 37C
Rattus norvegicus
0.002
-
ibogaine
pH 7.4, 37C
Rattus norvegicus
0.0023
-
6-oxocholestanol
pH 7.4, 37C
Rattus norvegicus
0.0023
-
rimcazole
pH 7.4, 37C
Rattus norvegicus
0.0035
-
AC-915
pH 7.4, 37C
Rattus norvegicus
0.0042
-
7-oxocholesterol
pH 7.4, 37C
Rattus norvegicus
0.0061
-
7alpha-hydroxycholesterol
pH 7.4, 37C
Rattus norvegicus
0.0069
-
7beta-hydroxycholesterol
pH 7.4, 37C
Rattus norvegicus
0.0085
-
6-oxo-5-alpha-hydroxycholestanol
pH 7.4, 37C
Rattus norvegicus
0.0091
-
(E)-N,3,6,6-tetra methyl-N-(naphthalene-1-ylmethyl)hept-2-en-4-yn-1-amine
pH 7.4, 37C
Rattus norvegicus
0.0097
-
cholestane-3beta,5alpha,6beta-triol
pH 7.4, 37C
Rattus norvegicus
0.012
-
docosahexaenoic acid
pH 7.4, 37C
Rattus norvegicus
0.018
-
4-(4-(4-chloro phenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
pH 7.4, 37C
Rattus norvegicus
0.024
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.0363
-
alpha-linolenic acid
pH 7.4, 37C
Rattus norvegicus
0.054
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0074
-
5,6alpha-epoxy-5alpha-cholestan-3beta-ol
pH 7.4, 37C
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
706552
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O
-
706552
Rattus norvegicus
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O
-
706552
Homo sapiens
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O
-
706552
Rattus norvegicus
5alpha-cholestane-3beta,5alpha,6beta-triol
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Rattus norvegicus
General Information
General Information
Commentary
Organism
malfunction
knockdown of D8D7I (3beta-hydroxysterol-DELTA8-DELTA7-isomerase) and DHCR7 (3beta-hydroxysterol-DELTA7-reductase) abolishes ChEH activity. D8D7I and DHCR7 cooperate in the ChEH activity
Homo sapiens
physiological function
the existence of ChEH activity in MCF-7 cells, and thus ChEH inhibition and accumulation are likely to play a role in the mechanism of induction of breast cancer cell differentiation and apoptosis by antiestrogen binding site (AEBS) ligands that require sterol autoxidation products
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
knockdown of D8D7I (3beta-hydroxysterol-DELTA8-DELTA7-isomerase) and DHCR7 (3beta-hydroxysterol-DELTA7-reductase) abolishes ChEH activity. D8D7I and DHCR7 cooperate in the ChEH activity
Homo sapiens
physiological function
the existence of ChEH activity in MCF-7 cells, and thus ChEH inhibition and accumulation are likely to play a role in the mechanism of induction of breast cancer cell differentiation and apoptosis by antiestrogen binding site (AEBS) ligands that require sterol autoxidation products
Homo sapiens
Other publictions for EC 3.3.2.11
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743697
Voisin
Identification of a tumor-pro ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
114
E9346-E9355
2017
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731280
Segala
5,6-Epoxy-cholesterols contrib ...
Homo sapiens
Biochem. Pharmacol.
86
175-189
2013
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731385
Poirot
Cholesterol-5,6-epoxides: chem ...
Rattus norvegicus
Biochimie
95
622-631
2013
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731693
Silvente-Poirot
Cholesterol epoxide hydrolase ...
Homo sapiens
Curr. Opin. Pharmacol.
12
696-703
2012
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706552
de Medina
Identification and pharmacolog ...
Homo sapiens, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
107
13520-13525
2010
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661023
Palakodety
Microsomal cholesterol epoxide ...
Rattus norvegicus
Biochem. Pharmacol.
36
2424-2427
1987
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660845
Watabe
Hepatic microsomal cholesterol ...
Mus musculus
Biochem. Biophys. Res. Commun.
140
632-637
1986
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661275
Astroem
Subcellular and organ distribu ...
Rattus norvegicus
Biochim. Biophys. Acta
882
359-366
1986
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662082
Nashed
7-Dehydrocholesterol 5,6 beta- ...
Rattus norvegicus
J. Biol. Chem.
261
2510-2513
1986
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662084
Sevanian
Catalytic properties and inhib ...
Rattus norvegicus
J. Biol. Chem.
261
54-59
1986
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660783
Nashed
Properties of liver microsomal ...
Homo sapiens, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Arch. Biochem. Biophys.
241
149-162
1985
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661435
Oesch
Existence of multiple forms of ...
Oryctolagus cuniculus, Rattus norvegicus
Carcinogenesis
5
7-9
1984
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660782
Levin
Distinct rat hepatic microsoma ...
Rattus norvegicus
Arch. Biochem. Biophys.
220
485-494
1983
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