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Literature summary for 3.3.2.11 extracted from

  • Oesch, F.; Timms, C.W.; Walker, C.H.; Guenthner, T.M.; Sparrow, A.; Watabe, T.; Wolf, C.R.
    Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities (1984), Carcinogenesis, 5, 7-9.
    View publication on PubMed
Search for more literature for 3.3.2.11

Inhibitors

Inhibitors Comment Organism Structure
5,6alpha-imino-5alpha-cholestane-3beta-ol specific inhibition of cholesterol-5,6-epoxide hydrolase Oryctolagus cuniculus
5,6alpha-imino-5alpha-cholestane-3beta-ol specific inhibition of cholesterol-5,6-epoxide hydrolase Rattus norvegicus
additional information no inhibition by 1,1,1-trichloropropene oxide Oryctolagus cuniculus
additional information no inhibition by 1,1,1-trichloropropene oxide Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O Rattus norvegicus the enzyme is highly substrate-specific cholestane-3beta,5alpha,6beta-triol
-
 ?
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O Oryctolagus cuniculus the enzyme is highly substrate-specific cholestane-3beta,5alpha,6beta-triol
-
 ?
additional information Rattus norvegicus the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity ?
-
 ?
additional information Oryctolagus cuniculus the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 New Zealand white rabbits
-
Rattus norvegicus
-
 male Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
from microsomes, separation from EC 3.3.2.9 by immunoprecipitation Rattus norvegicus
from microsomes, separation from EC 3.3.2.9 by immunoprecipitation Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O the enzyme is highly substrate-specific Rattus norvegicus cholestane-3beta,5alpha,6beta-triol
-
 ?
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O the enzyme is highly substrate-specific Oryctolagus cuniculus cholestane-3beta,5alpha,6beta-triol
-
 ?
additional information the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity Rattus norvegicus ?
-
 ?
additional information the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9, which shows a wider substrate specificity Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 5alpha,6alpha-oxide hydrolase
-
 Rattus norvegicus
cholesterol 5alpha,6alpha-oxide hydrolase
-
 Oryctolagus cuniculus
EH_CH
-
 Rattus norvegicus
EH_CH
-
 Oryctolagus cuniculus