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Literature summary for 3.3.2.10 extracted from

  • Li, H.X.; Heo, M.; Go, Y.; Kim, Y.S.; Kim, Y.H.; Yang, S.Y.; Li, W.
    Coumarin and moracin derivatives from mulberry leaves (Morus alba L.) with soluble epoxide hydrolase inhibitory activity (2020), Molecules, 25, 3967.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aesculetin coumarin derivative from mulberry leaves, competitive Homo sapiens
moracin B isolated from mulberry leaves, competitive Homo sapiens
moracin J isolated from mulberry leaves, mixed type inhibitor Homo sapiens
moracin M isolated from mulberry leaves, mixed type inhibitor Homo sapiens
moracin M 3'-O-beta-glucopyranoside isolated from mulberry leaves, mixed-type inhibitor Homo sapiens
scopoletin coumarin derivative from mulberry leaves, competitive Homo sapiens
scopolin coumarin derivative from mulberry leaves, competitive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913 cf. EC 3.1.3.76
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
scopoletin pH 7, temperature not specified in the publication Homo sapiens
0.001
-
moracin B pH 7, temperature not specified in the publication Homo sapiens
0.0012
-
aesculetin pH 7, temperature not specified in the publication Homo sapiens
0.0015
-
moracin M pH 7, temperature not specified in the publication Homo sapiens
0.0021
-
moracin J pH 7, temperature not specified in the publication Homo sapiens
0.0054
-
scopolin pH 7, temperature not specified in the publication Homo sapiens
0.0058
-
moracin M 3'-O-beta-glucopyranoside pH 7, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
pH 7, temperature not specified in the publication Homo sapiens scopoletin
0.0011
-
pH 7, temperature not specified in the publication Homo sapiens moracin B
0.0012
-
pH 7, temperature not specified in the publication Homo sapiens moracin J
0.0069
-
pH 7, temperature not specified in the publication Homo sapiens aesculetin
0.0077
-
pH 7, temperature not specified in the publication Homo sapiens moracin M 3'-O-beta-glucopyranoside
0.0099
-
pH 7, temperature not specified in the publication Homo sapiens moracin M
0.0159
-
pH 7, temperature not specified in the publication Homo sapiens scopolin