Literature summary for 3.3.2.10 extracted from

Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Bloecher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fuerst, R.; Proschak, E.
Design, synthesis and cellular characterization of a dual inhibitor of 5-lipoxygenase and soluble epoxide hydrolase (2016), Molecules, 22, 45-54 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(3-(5-(hydroxyureido)methyl-2-methoxyphenoxy)propyl)-3-[4-(trifluoromethoxy)phenyl]urea	i.e. KM55, a dual inhibitor of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH), synthesis and evaluation, overview. Applied to leukocytes, it strongly inhibits the lipopolysaccharide (LPS)-induced adhesion of the leukocytes to endothelial cells. KM55 is a designed multi-target ligand which inhibits the enzymatic activity of 5-LO and sEH	Homo sapiens
N-cyclohexyl-N'-(4-iodophenyl)urea	CIU	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
epoxyeicosatrienoic acid + H2O	Homo sapiens	-	dihydroxyeicosatrienoic acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P34913	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methylester-2-oxirane-acetic acid + H2O	the non-fluorescent substrate can be hydrolyzed by enzyme sEH to the fluorescent 6-methoxynaphtaldehyde	Homo sapiens	6-methoxynaphtaldehyde + ?	-	?
epoxyeicosatrienoic acid + H2O	-	Homo sapiens	dihydroxyeicosatrienoic acid	-	?

Synonyms

Synonyms	Comment	Organism
SEH	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000029	-	recombinant enzyme, pH 7.0, 22°C	Homo sapiens	1-(3-(5-(hydroxyureido)methyl-2-methoxyphenoxy)propyl)-3-[4-(trifluoromethoxy)phenyl]urea
0.00014	-	recombinant enzyme, pH 7.0, 22°C	Homo sapiens	N-cyclohexyl-N'-(4-iodophenyl)urea

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Release 2023.1 (January 2023)