Literature summary for 3.3.2.10 extracted from

Lee, K.S.; Liu, J.Y.; Wagner, K.M.; Pakhomova, S.; Dong, H.; Morisseau, C.; Fu, S.H.; Yang, J.; Wang, P.; Ulu, A.; Mate, C.A.; Nguyen, L.V.; Hwang, S.H.; Edin, M.L.; Mara, A.A.; Wulff, H.; Newcomer, M.E.; Zeldin, D.C.; Hammock, B.D.
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy (2014), J. Med. Chem., 57, 7016-7030.

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 30% (w/v) PEG 3350, 0-10% (w/v) sucrose, at 4°C	Rattus norvegicus
hanging drop vapor diffusion method, using 30% (w/v) PEG 3350, 0-10% (w/v) sucrose, at 4°C	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-(1-acetypiperidin-4-yl)-3-adamantanylurea	-	Homo sapiens
1-(1-acetypiperidin-4-yl)-3-adamantanylurea	-	Rattus norvegicus
1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)-urea	-	Homo sapiens
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)-urea	-	Rattus norvegicus
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)-urea	-	Homo sapiens
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)-urea	-	Rattus norvegicus
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea	-	Homo sapiens
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea	-	Rattus norvegicus
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea	-	Homo sapiens
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea	-	Rattus norvegicus
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Homo sapiens
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Rattus norvegicus
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Homo sapiens
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Rattus norvegicus
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Homo sapiens
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Rattus norvegicus
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Homo sapiens
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	-	Rattus norvegicus
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Homo sapiens
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	-	Rattus norvegicus
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	-	Homo sapiens
1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	-	Rattus norvegicus
2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide	-	Homo sapiens
2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide	-	Rattus norvegicus
N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide	-	Homo sapiens
N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide	-	Rattus norvegicus
trans-4-[4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy]benzoic acid	-	Homo sapiens
trans-4-[4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy]benzoic acid	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Rattus norvegicus	-	-
soluble	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P34913	-	-
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
SEH	-	Rattus norvegicus
SEH	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.00000002	-	1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000002	-	1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	Ki below 0.00000002 mM, in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000019	-	1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000022	-	1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000023	-	1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000031	-	1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000036	-	1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000037	-	1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000043	-	1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000044	-	1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000049	-	1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000049	-	1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000066	-	1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000091	-	1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000098	-	1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000099	-	1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000117	-	1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000117	-	1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.0000012	-	1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000122	-	1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000147	-	1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000174	-	1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000179	-	1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000223	-	1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000244	-	1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000296	-	1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000423	-	1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.00000716	-	1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.0000112	-	2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.0000146	-	1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens
0.000111	-	N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00000125	-	IC50 below 0.00000125 mM, in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Rattus norvegicus	1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
0.0000018	-	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Rattus norvegicus	1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
0.0000133	-	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Rattus norvegicus	1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
0.00002	-	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Rattus norvegicus	1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
0.0000291	-	in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C	Rattus norvegicus	1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea