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Literature summary for 3.3.2.10 extracted from

  • la Buscato, E.; Bloecher, R.; Lamers, C.; Klingler, F.M.; Hahn, S.; Steinhilber, D.; Schubert-Zsilavecz, M.; Proschak, E.
    Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors (2012), J. Med. Chem., 55, 10771-10775.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-[3-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
 Homo sapiens
ethyl 1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-[2-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
-
 Homo sapiens
ethyl 1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
-
 Homo sapiens 6-methoxynaphthaldehyde + ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000023
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
0.000027
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
0.000039
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
0.000043
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
0.000046
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
0.000073
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
0.000087
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
0.000107
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 12-(3-adamantan-1-yl-ureido)dodecanoic acid
0.000178
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
0.000252
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
0.000258
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
0.000304
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
0.000611
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
0.000747
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
0.000943
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-[3-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
0.001923
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens 1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
0.002009
-
 in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C Homo sapiens ethyl 1-[2-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate