Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.3.2.10 extracted from

  • Kim, I.H.; Lee, I.H.; Nishiwaki, H.; Hammock, B.D.; Nishi, K.
    Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase (2014), Bioorg. Med. Chem., 22, 1163-1175.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)-3-adamantylurea
-
 Homo sapiens
1-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)-3-adamantylurea
-
 Homo sapiens
1-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)-3-adamantylurea
-
 Homo sapiens
1-(4-(N2-methyloxyoxalamido)benzyl)-3-adamantylurea
-
 Homo sapiens
1-(4-(N2-tert-butyloxyoxalamido)benzyl)-3-adamantylurea
-
 Homo sapiens
1-benzyl-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
 Homo sapiens
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
 Homo sapiens
IK950
-
 Homo sapiens
methyl 4-[[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)amino]methyl]benzoate
-
 Homo sapiens
N-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)adamantanecarboxamide
-
 Homo sapiens
N-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)adamantanecarboxamide
-
 Homo sapiens
N-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)adamantanecarboxamide
-
 Homo sapiens
N-(4-(N2-methyloxyoxalamido)benzyl)adamantanecarboxamide
-
 Homo sapiens
N-(4-(N2-tert-butyloxyoxalamido)benzyl)adamantanecarboxamide
-
 Homo sapiens
N-(benzyloxy)-2-(adamant-2-ylamino)acetamide
-
 Homo sapiens
N-benzyltricyclo[3.3.1.13,7]decane-1-carboxamide
-
 Homo sapiens
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N1-methyl-N2-methyl-N2-methyloxyoxalamide
-
 Homo sapiens
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N2-methyl-N2-methyloxyoxalamide
-
 Homo sapiens
N1-(4-(2-adamantylacetamido)phenyl)-N1-methyl-N2-methyl-N2-(methyloxy)oxalamide
-
 Homo sapiens
N1-(4-(2-adamantylacetamido)phenyl)-N2-methyl-N2-(methyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-1-yl)-N2-(benzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-1-ylmethyl)-N2-(benzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(2-phenylethyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(3-phenylpropyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(4-chlorobenzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(4-methoxycarbonylbenzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(4-nitrobenzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(benzyloxy)-N2-methyloxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(benzyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(phenyloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-(tetrahydro-2H-pyran-2-yloxy)oxalamide
-
 Homo sapiens
N1-(adamant-2-yl)-N2-methyl-N2-(methyloxy)oxalamide
-
 Homo sapiens
N1-(benzyloxy)-N2-(3-phenylpropyl)oxalamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyano-(2-methoxynaphthalen-6-yl)-methyl trans-(3-phenyl-oxiran-2-yl)-methyl carbonate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000012
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)-3-adamantylurea
0.0000032
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 12-(3-adamantan-1-yl-ureido)dodecanoic acid
0.0000044
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(4-(2-adamantylacetamido)phenyl)-N1-methyl-N2-methyl-N2-(methyloxy)oxalamide
0.000005
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)-3-adamantylurea
0.0000066
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-(4-(N2-methyloxyoxalamido)benzyl)-3-adamantylurea
0.0000079
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(4-((2-adamantylacetamido)methyl)phenyl)-N1-methyl-N2-methyl-N2-methyloxyoxalamide
0.0000091
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens methyl 4-[[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)amino]methyl]benzoate
0.000014
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens IK950
0.000016
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-benzyl-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.000019
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-(4-(N2-tert-butyloxyoxalamido)benzyl)-3-adamantylurea
0.000019
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens 1-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)-3-adamantylurea
0.000035
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(4-(2-adamantylacetamido)phenyl)-N2-methyl-N2-(methyloxy)oxalamide
0.00005
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(benzyloxy)oxalamide
0.000069
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(4-((2-adamantylacetamido)methyl)phenyl)-N2-methyl-N2-methyloxyoxalamide
0.00018
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(4-(N2-methyloxyoxalamido)benzyl)adamantanecarboxamide
0.00019
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)adamantanecarboxamide
0.000204
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)adamantanecarboxamide
0.000408
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(4-(N2-tert-butyloxyoxalamido)benzyl)adamantanecarboxamide
0.00055
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(3-phenylpropyloxy)oxalamide
0.000838
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-1-ylmethyl)-N2-(benzyloxy)oxalamide
0.001
-
 IC50 above 0.001 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-benzyltricyclo[3.3.1.13,7]decane-1-carboxamide
0.001
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)adamantanecarboxamide
0.0015
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(4-methoxycarbonylbenzyloxy)oxalamide
0.0023
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(4-chlorobenzyloxy)oxalamide
0.0032
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(benzyloxy)-N2-methyloxalamide
0.0044
-
 in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(2-phenylethyloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(benzyloxy)-N2-(3-phenylpropyl)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-1-yl)-N2-(benzyloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(phenyloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(4-nitrobenzyloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-methyl-N2-(methyloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N1-(adamant-2-yl)-N2-(tetrahydro-2H-pyran-2-yloxy)oxalamide
0.01
-
 IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C Homo sapiens N-(benzyloxy)-2-(adamant-2-ylamino)acetamide