Any feedback?
Literature summary for 3.3.2.10 extracted from
- Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 417-421.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-4-carboxamide | - |
Homo sapiens |  |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-fluorophenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-hydroxyphenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylphenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylpropyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-fluorophenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-hydroxyphenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-methoxyphenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-nitrophenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-phenoxyphenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(6-methoxy-1,3-benzodioxol-5-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(isoquinolin-5-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(naphthalen-2-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-3-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-6-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-8-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-(tricyclo[3.3.1.13,7]dec-1-yl)piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-phenylpiperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[(1R,2S)-2-phenylcyclopropyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(morpholin-4-yl)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(piperidin-1-yl)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(propan-2-yl)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-[(trifluoromethyl)sulfonyl]phenyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoic acid | - |
Homo sapiens | |
| 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylic acid | - |
Homo sapiens | |
| methyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoate | - |
Homo sapiens | |
| methyl 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylate | - |
Homo sapiens | |
| N-(1,3-benzodioxol-5-yl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(2-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(2-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(3,4-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(3,5-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(4-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(4-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-(cyclohexylmethyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cyclobutyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cycloheptyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cyclohexyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cyclooctyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cyclopentyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-cyclopropyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-[3-carbamoyl-4-(piperidin-1-yl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| N-[4-chloro-3-(trifluoromethyl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | - |
Homo sapiens | |
| tert-butyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]piperidine-1-carboxylate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl)methyl carbonate + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000004 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-hydroxyphenyl)piperidine-4-carboxamide | |
| 0.0000006 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000006 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylic acid | |
| 0.0000011 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-fluorophenyl)piperidine-4-carboxamide | |
| 0.0000012 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-hydroxyphenyl)piperidine-4-carboxamide | |
| 0.0000016 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-[(trifluoromethyl)sulfonyl]phenyl]piperidine-4-carboxamide | |
| 0.0000017 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(tricyclo[3.3.1.13,7]dec-1-yl)piperidine-4-carboxamide | |
| 0.0000023 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-3-yl)piperidine-4-carboxamide | |
| 0.0000026 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cycloheptyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000028 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclooctyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000046 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclopropyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000052 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclopentyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000052 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(1,3-benzodioxol-5-yl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000058 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(cyclohexylmethyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000006 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-8-yl)piperidine-4-carboxamide | |
| 0.0000067 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(propan-2-yl)phenyl]piperidine-4-carboxamide | |
| 0.0000069 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-phenylpiperidine-4-carboxamide | |
| 0.0000079 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0000083 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(naphthalen-2-yl)piperidine-4-carboxamide | |
| 0.0000085 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoate | |
| 0.0000087 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(2-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000012 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-nitrophenyl)piperidine-4-carboxamide | |
| 0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-6-yl)piperidine-4-carboxamide | |
| 0.000017 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoic acid | |
| 0.000018 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylpropyl)piperidine-4-carboxamide | |
| 0.00002 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(piperidin-1-yl)phenyl]piperidine-4-carboxamide | |
| 0.00002 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylphenyl)piperidine-4-carboxamide | |
| 0.00002 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-phenoxyphenyl)piperidine-4-carboxamide | |
| 0.000023 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-4-carboxamide | |
| 0.000023 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(isoquinolin-5-yl)piperidine-4-carboxamide | |
| 0.000025 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3,5-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000025 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-methoxyphenyl)piperidine-4-carboxamide | |
| 0.000029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclobutyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.00003 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide | |
| 0.000041 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-4-carboxamide | |
| 0.000043 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[3-carbamoyl-4-(piperidin-1-yl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000045 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000055 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(3,4-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000078 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-chloro-3-(trifluoromethyl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.000102 | - |
pH and temperature not specified in the publication | Homo sapiens | N-cyclohexyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.00011 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylate | |
| 0.00025 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(morpholin-4-yl)phenyl]piperidine-4-carboxamide | |
| 0.000263 | - |
pH and temperature not specified in the publication | Homo sapiens | tert-butyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]piperidine-1-carboxylate | |
| 0.00029 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-fluorophenyl)piperidine-4-carboxamide | |
| 0.00064 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide | |
| 0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide | |
| 0.0069 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-[(1R,2S)-2-phenylcyclopropyl]piperidine-4-carboxamide | |
| 0.03 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-[(2,4-dimethylphenyl)sulfonyl]-N-(6-methoxy-1,3-benzodioxol-5-yl)piperidine-4-carboxamide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
