Literature summary for 3.3.2.10 extracted from

Kim, I.H.; Park, Y.K.; Hammock, B.D.; Nishi, K.
Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase (2011), J. Med. Chem., 54, 1752-1761.

Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment)	Organism
expression in baculoviral system	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
methyl 4-((1,2,3,4-tetrahydronaphthalene-2-carboxamido)methyl)benzoic acid	-	Homo sapiens
methyl 4-([[(6-hydroxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate	-	Homo sapiens
methyl 4-([[(6-methoxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyloxiran-2-yl)methylcarbonate + H2O	-	Homo sapiens	?	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000018	-	pH 7.0, 30°C	Homo sapiens	methyl 4-([[(6-hydroxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate
0.0000021	-	pH 7.0, 30°C	Homo sapiens	methyl 4-((1,2,3,4-tetrahydronaphthalene-2-carboxamido)methyl)benzoic acid
0.0000024	-	pH 7.0, 30°C	Homo sapiens	methyl 4-([[(6-methoxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate

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Release 2023.1 (January 2023)