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Literature summary for 3.3.2.10 extracted from

  • Nayeem, M.A.; Zeldin, D.C.; Boegehold, M.A.; Morisseau, C.; Marowsky, A.; Ponnoth, D.S.; Roush, K.P.; Falck, J.R.
    Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase (2010), Am. J. Physiol. Regul. Integr. Comp. Physiol., 299, R325-R333.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine modulation of the vascular response mediated through adenosine A2A receptor using aortas from mice fed a 4% NaCl high salt or 0.45% NaCl low salt diet for 4-5 weeks. Compared with NS, HS vessels show increased CYP2J2 and A2A adenosine receptor expression but decreased sEH, CYP4A, and A1 adenosine receptor expression. Data suggest that in mice fed low salt containing diet, upregulation of arterial A1 receptor causes vasoconstriction via increased sEH and CYP4A proteins. In mice fed high salt-containing diet, upregulation of A2A receptor protein triggers vascular relaxation through ATP-sensitive channels via upregulation of CYP2J2 enzyme Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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 Mus musculus
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