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Literature summary for 3.3.2.10 extracted from

  • Marowsky, A.; Burgener, J.; Falck, J.R.; Fritschy, J.M.; Arand, M.
    Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism (2009), Neuroscience, 163, 646-661.
    View publication on PubMed
Search for more literature for 3.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
expression pattern of sEH Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-adamantyl-3-cyclohexylurea a sEH-selective inhibitor Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid
-
 Mus musculus
0.002
-
 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid
-
 Mus musculus
0.002
-
 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid
-
 Mus musculus
0.006
-
 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Mus musculus
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Mus musculus C57BL/6
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P34914 C57BL/6 mice
-
Mus musculus C57BL/6 P34914 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Mus musculus
-
astrocyte
-
 Mus musculus
-
brain sEH distribution, immunohistochemical analysis, overview. sEH immunoreactivity is almost exclusively located in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus C57BL/6 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus

General Information

General Information Comment Organism
metabolism epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Soluble epoxide hydrolase mediates the bulk of the cerebral epoxyeicosatrienoic acid metabolism, overview Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.005
-
 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid
-
 Mus musculus
0.005
-
 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid
-
 Mus musculus
0.05
-
 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid
-
 Mus musculus
0.5
-
 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid
-
 Mus musculus