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Literature summary for 3.3.2.10 extracted from

  • Shen, H.; Ding, F.; Wang, S.; Deng, Q.; Zhang, X.; Chen, Y.; Zhou, G.; Xu, S.; Chen, H.; Tong, X.; Tong, V.; Mitra, K.; Kumar, S.; Tsai, C.; Stevenson, A.; Pai, L.; Alonso-Galicia, M.; Chen, X.; Soisson, S.; Roy, S.; Zhang, B.; Tata, J.; Berger, J.; Colle
    Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement (2009), J. Med. Chem., 52, 5009-5012.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
4-(1,2,4-oxadiazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(1,3,4-oxadiazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(1,3-benzoxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(1-methyl-1H-1,2,3-triazol-4-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(2,3-dihydro-1H-1,2,3-triazol-1-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(3-hydroxy-4-methyl-1,2-oxazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(4-methyl-4H-1,2,4-triazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-(5-[1-[(2-phenylcyclopropyl)carbamoyl]piperidin-4-yl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
 Homo sapiens
4-[3-(isoquinolin-1-yl)-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidine-1-carboxamide
-
 Homo sapiens
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)piperidine-1-carboxamide
-
 Homo sapiens
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide
-
 Homo sapiens
4-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
 Homo sapiens
N-(2,3-dihydro-1H-inden-1-yl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-(1H-1,2,4-triazol-1-yl)piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-(1H-pyrazol-1-yl)piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens
N-(2-phenylcyclopropyl)-4-[3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
-
 Homo sapiens 4-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.000005
-
-
 Homo sapiens 4-(5-[1-[(2-phenylcyclopropyl)carbamoyl]piperidin-4-yl]-1,2,4-oxadiazol-3-yl)benzoic acid
0.000007
-
-
 Homo sapiens 4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide
0.000007
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000007
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.0000075
-
-
 Homo sapiens 4-(1,3-benzoxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.000008
-
-
 Homo sapiens 4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidine-1-carboxamide
0.000009
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000009
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.00001
-
-
 Homo sapiens 4-[3-(isoquinolin-1-yl)-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.000013
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000014
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000028
-
-
 Homo sapiens 4-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.000033
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-[3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000036
-
-
 Homo sapiens 4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)piperidine-1-carboxamide
0.000054
-
-
 Homo sapiens 4-(1,2,4-oxadiazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.00012
-
-
 Homo sapiens 4-(1-methyl-1H-1,2,3-triazol-4-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.00013
-
-
 Homo sapiens N-(2,3-dihydro-1H-inden-1-yl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
0.000235
-
-
 Homo sapiens 4-(1,3,4-oxadiazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.00043
-
-
 Homo sapiens 4-(2,3-dihydro-1H-1,2,3-triazol-1-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.00048
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-(1H-pyrazol-1-yl)piperidine-1-carboxamide
0.0011
-
-
 Homo sapiens 4-(3-hydroxy-4-methyl-1,2-oxazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
0.0011
-
-
 Homo sapiens N-(2-phenylcyclopropyl)-4-(1H-1,2,4-triazol-1-yl)piperidine-1-carboxamide
0.0084
-
-
 Homo sapiens 4-(4-methyl-4H-1,2,4-triazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide