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Literature summary for 3.3.2.10 extracted from
- Pharmacological inhibition of the soluble epoxide hydrolase-from mouse to man (2010), Curr. Opin. Pharmacol., 10, 173-178.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | sEH inhibitors are 1,3-disubstituted ureas, amides and carbamates that have IC50-values in the low nanomolar range. They only block the hydrolase activity of the enzyme without affecting the phosphatase domain | Mammalia |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Mammalia | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
2 * 62000 | Mammalia |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Mammalia | - |
| kidney | - |
Mammalia | - |
| additional information | sEH is ubiquituously expressed | Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme possesses an epoxide hydrolyzing as well as a lipid phosphatase activity. Favored sEH substrates are trans-substituted over cis-substituted epoxides | Mammalia | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 62000 | Mammalia |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Mammalia |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | sEh inhibition reduces inflammation. In several mouse models, sEH inhibition reduces atherosclerosis and aortic aneurysm formation. The anti-proliferative effect of urea-based sEH inhibitors is probably caused by PPARa activation and consecutive inhibition of cyclin D1 expression. And sEH inhibition affects renal fucntions, overview | Mammalia |
| physiological function | sEH is not essentially involved in the metabolization and clearance of carcinogenic xenobiotics. But sEH is involved in inflammation | Mammalia |
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