Cloned (Comment) | Organism |
---|---|
gene Ephx2, located on chromosome 8p21-p12 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C780T | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
G1465A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
G405A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
G560A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
additional information | increased sEH gene expression and activity along with renal eicosanoid metabolism participate in the pathogenesis of hypertension in SHRs | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea | i.e. AR9276, reduces atherosclerotic lesions in the aorta and carotid artery and attenuates abdominal aortic aneurysm formation in apolipoprotein E-deficient mice | Mus musculus | |
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea | i.e. AR9276 | Rattus norvegicus | |
1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea | - |
Mus musculus | |
1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea | - |
Rattus norvegicus | |
additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Mus musculus | |
additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Homo sapiens | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Homo sapiens | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34913 | gene EPHX2 | - |
Mus musculus | P34914 | - |
- |
Rattus norvegicus | P80299 | Wistar-Kyoto rats and Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
blood vessel | - |
Homo sapiens | - |
carotid artery | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | laboratory rats have by far the lowest levels of hepatic sEH among the mammals studied | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |
SEH | - |
Homo sapiens |
SEH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Mus musculus |
malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Homo sapiens |
malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Rattus norvegicus |
additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Mus musculus |
additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Rattus norvegicus |