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Literature summary for 3.3.2.10 extracted from

  • Bianco, R.A.; Agassandian, K.; Cassell, M.D.; Spector, A.A.; Sigmund, C.D.
    Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase (2009), Brain Res., 1291, 60-72.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
medicine since the metabolism of EETs by sEH reduces or eliminates their bioactivity, inhibition of sEH has become a therapeutic strategy for hypertension and inflammation Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of a transgenic mouse model, which overexpresses sEH specifically in neurons. Transgenic mice show increased neuron labeling in cortex and hippocampus with little change in labeling of other brain regions. Despite a 3fold increase in sEH activity in the brain, there is no change in arterial pressure. Immunohistochemical examination of transgenic mouse brain regions, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P34914
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cortical and hippocampal Mus musculus
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brain wide expression of sEH in cortical and hippocampal astrocytes and also in a few specific neuron types in the cortex, cerebellum, and medulla, immunohistochemical analysis, overview Mus musculus
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brain cortex
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cerebellum
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medulla oblongata
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 Mus musculus
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additional information sEH is found in nearly all tissues Mus musculus
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neuron
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Synonyms

Synonyms Comment Organism
SEH
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 Mus musculus

General Information

General Information Comment Organism
metabolism soluble epoxide hydrolase is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids, EETs Mus musculus
physiological function soluble epoxide hydrolase is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids, EETs. In the central nervous system, EETs are thought to play a role in the regulation of local blood flow, protection from ischemic injury, inhibition of inflammation, the release of peptide hormones and modulation of fever Mus musculus