Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | induces sEH activity | Homo sapiens | |
peroxisome proliferator-activated receptor alpha | strong inducer of sEH | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Phenylchalcone oxide | - |
Homo sapiens | |
carbofuran | - |
Homo sapiens | |
chlorpropham | - |
Homo sapiens | |
Cyclohexene oxide | weak inhibitor | Homo sapiens | |
dicyclohexyl urea | - |
Homo sapiens | |
Diflubenzuron | - |
Homo sapiens | |
diuron impurity | - |
Homo sapiens | |
N-(1-(2,2,2-trifluoroethanoyl)piperidin-4-yl)-N'-(adamant-1-yl)urea | - |
Homo sapiens | |
siduron | - |
Homo sapiens | |
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid | - |
Homo sapiens | |
trichloropropene oxide | weak inhibitor | Homo sapiens | |
triclocarban | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62500 | - |
2 * 62500 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | exceptionally high concentration in the kidney | Homo sapiens | - |
liver | exceptionally high concentration in the liver | Homo sapiens | - |
vascular endothelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
cis-stilbene oxide + H2O | - |
Homo sapiens | (1R,2R)-1,2-diphenylethane-1,2-diol | - |
? | |
squalene oxide + H2O | weak substrate | Homo sapiens | ? | - |
? | |
styrene oxide + H2O | very poor substrate for sEH | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 62500 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
EC 3.3.2.3 | - |
Homo sapiens |
SEH | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
sEH is largely inactive at basic pH values | Homo sapiens |