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Literature summary for 3.3.2.10 extracted from

  • Gross, G.J.; Nithipatikom, K.
    Soluble epoxide hydrolase: a new target for cardioprotection (2009), Curr. Opin. Investig. Drugs, 10, 253-258.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
medicine allelic variation of EPHX2 is associated with heart failure Mus musculus
medicine allelic variation of EPHX2 is associated with heart failure Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
 Mus musculus
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
 Rattus norvegicus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester selective soluble epoxide hydrolase inhibitor Mus musculus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester selective soluble epoxide hydrolase inhibitor Rattus norvegicus
12-(3-adamantan-1-yl-ureido)dodecanoic acid selective soluble epoxide hydrolase inhibitor Mus musculus
12-(3-adamantan-1-yl-ureido)dodecanoic acid selective soluble epoxide hydrolase inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O i.e. 14,15-EET Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid i.e. 14,15-DHET ?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O i.e. 14,15-EET Rattus norvegicus (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid i.e. 14,15-DHET ?

Synonyms

Synonyms Comment Organism
EPHX2
-
 Mus musculus
EPHX2
-
 Rattus norvegicus
SEH
-
 Mus musculus
SEH
-
 Rattus norvegicus