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Literature summary for 3.3.2.10 extracted from

  • Xie, Y.; Liu, Y.; Gong, G.; Smith, D.H.; Yan, F.; Rinderspacher, A.; Feng, Y.; Zhu, Z.; Li, X.; Deng, S.X.; Branden, L.; Vidovi?, D.; Chung, C.; Schuerer, S.; Morisseau, C.; Hammock, B.D.; Landry, D.W.
    Discovery of potent non-urea inhibitors of soluble epoxide hydrolase (2009), Bioorg. Med. Chem. Lett., 19, 2354-2359.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
medicine sEH is a target for the treatment of hypertension and vascular inflammation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,1'-(benzene-1,3-diyldicarbonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide] 55% inhibition at 200 nM Homo sapiens
1,1'-(benzene-1,3-diyldisulfonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide] 45% inhibition at 200 nM Homo sapiens
1-(cyclohexylsulfonyl)-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 27% inhibition at 200 nM Homo sapiens
1-[(1-chloroisoquinolin-5-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 30% inhibition at 200 nM Homo sapiens
1-[(2-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 63% inhibition at 200 nM Homo sapiens
1-[(2-chloroethyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 31% inhibition at 200 nM Homo sapiens
1-[(4-bromoisoquinolin-5-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 37% inhibition at 200 nM Homo sapiens
1-[(4-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 32% inhibition at 200 nM Homo sapiens
1-[(4-chloro-2,5-dimethylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
1-[(4-tert-butylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 85% inhibition at 200 nM Homo sapiens
1-[(5-bromothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 43% inhibition at 200 nM Homo sapiens
1-[(5-chlorothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 52% inhibition at 200 nM Homo sapiens
1-[[4-(acetylamino)phenyl]sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide 53% inhibition at 200 nM Homo sapiens
4,5-dimethoxy-2-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate 71% inhibition at 200 nM Homo sapiens
4-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate 41% inhibition at 200 nM Homo sapiens
N'-(2-chlorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide 62% inhibition at 200 nM Homo sapiens
N'-(4-fluorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide 9% inhibition at 200 nM Homo sapiens
N'-phenyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide 16% inhibition at 200 nM Homo sapiens
N'-[2-(3-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide 65% inhibition at 200 nM Homo sapiens
N-((1-acetylpiperidin-4-yl)methyl)-N'-(adamant-1-yl)urea
-
 Homo sapiens
N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 79% inhibition at 200 nM Homo sapiens
N-(1-tert-butoxypiperidin-4-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 88% inhibition at 200 nM Homo sapiens
N-(2,3-dihydro-1H-inden-2-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 62% inhibition at 200 nM Homo sapiens
N-(2,4-dichloro-6-methylbenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 95% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-(diphenylphosphanyl)piperidine-4-carboxamide 3% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-(methylsulfonyl)piperidine-4-carboxamide 45% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-(quinolin-5-ylsulfonyl)piperidine-4-carboxamide 34% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-(thiophen-2-ylcarbonyl)piperidine-4-carboxamide 16% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-([1-[(2,4,6-trimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)piperidine-4-carboxamide 31% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(1-methylethyl)sulfonyl]piperidine-4-carboxamide 13% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2,4,6-tri-tert-butylphenyl)sulfonyl]piperidine-4-carboxamide 88% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)carbonyl]piperidine-4-carboxamide 34% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2-fluorophenyl)sulfonyl]piperidine-4-carboxamide 66% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2-nitrophenyl)carbonyl]piperidine-4-carboxamide 44% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(2-nitrophenyl)sulfonyl]piperidine-4-carboxamide 47% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(3-nitrophenyl)carbonyl]piperidine-4-carboxamide 18% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(3-nitrophenyl)sulfonyl]piperidine-4-carboxamide 21% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(4-fluoro-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide 63% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 98% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(4-methyl-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide 28% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide 15% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[[2-(trifluoromethyl)phenyl]sulfonyl]piperidine-4-carboxamide 39% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]piperidine-4-carboxamide 37% inhibition at 200 nM Homo sapiens
N-(2,4-dichlorobenzyl)-1-[[3-([4-[(2,4-dichlorobenzyl)carbamoyl]piperidin-1-yl]carbonyl)phenyl]sulfonyl]piperidine-4-carboxamide 45% inhibition at 200 nM Homo sapiens
N-(2,4-difluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(2,5-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 98% inhibition at 200 nM Homo sapiens
N-(2-chloro-4-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 98% inhibition at 200 nM Homo sapiens
N-(2-chloro-6-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(2-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 90% inhibition at 200 nM Homo sapiens
N-(2-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 77% inhibition at 200 nM Homo sapiens
N-(2-phenylethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 67% inhibition at 200 nM Homo sapiens
N-(3,3-diphenylpropyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 78% inhibition at 200 nM Homo sapiens
N-(3,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(3-methylbutyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 87% inhibition at 200 nM Homo sapiens
N-(4-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 97% inhibition at 200 nM Homo sapiens
N-(4-chloronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 44% inhibition at 200 nM Homo sapiens
N-(4-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 86% inhibition at 200 nM Homo sapiens
N-(cyclohexylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 92% inhibition at 200 nM Homo sapiens
N-(naphthalen-1-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 55% inhibition at 200 nM Homo sapiens
N-(pyridin-3-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 23% inhibition at 200 nM Homo sapiens
N-(pyridin-4-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 49% inhibition at 200 nM Homo sapiens
N-benzyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 65% inhibition at 200 nM Homo sapiens
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 90% inhibition at 200 nM Homo sapiens
N-cyclohexyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 87% inhibition at 200 nM Homo sapiens
N-cyclopentyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 75% inhibition at 200 nM Homo sapiens
N-morpholin-4-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 14% inhibition at 200 nM Homo sapiens
N-naphthalen-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 50% inhibition at 200 nM Homo sapiens
N-phenyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 48% inhibition at 200 nM Homo sapiens
N-piperidin-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 55% inhibition at 200 nM Homo sapiens
N-piperidin-4-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 15% inhibition at 200 nM Homo sapiens
N-tert-butyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 3% inhibition at 200 nM Homo sapiens
N-[(4-chlorophenyl)(phenyl)methyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 7% inhibition at 200 nM Homo sapiens
N-[1-(4-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 94% inhibition at 200 nM Homo sapiens
N-[2-(4-methoxyphenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 44% inhibition at 200 nM Homo sapiens
N-[2-chloro-5-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 94% inhibition at 200 nM Homo sapiens
N-[4-chloro-3-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide 96% inhibition at 200 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
-
 Homo sapiens [1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
-
 ?

Synonyms

Synonyms Comment Organism
EPHX2
-
 Homo sapiens
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000079
-
-
 Homo sapiens N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.000011
-
-
 Homo sapiens N-(1-tert-butoxypiperidin-4-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000126
-
-
 Homo sapiens N-(cyclohexylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000127
-
-
 Homo sapiens N-(2-chloro-6-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000164
-
-
 Homo sapiens N-cyclohexyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.00002
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000201
-
-
 Homo sapiens N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000239
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000251
-
-
 Homo sapiens N-(3-methylbutyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000274
-
-
 Homo sapiens N-(2-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000287
-
-
 Homo sapiens N-[2-chloro-5-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000291
-
-
 Homo sapiens N-[1-(4-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.000032
-
-
 Homo sapiens N-(3,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000322
-
-
 Homo sapiens N-(2,4-difluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000336
-
-
 Homo sapiens N'-(2-chlorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
0.000035
-
-
 Homo sapiens N-(3,3-diphenylpropyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000372
-
-
 Homo sapiens N-(2-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000373
-
-
 Homo sapiens N-cyclopentyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000394
-
-
 Homo sapiens N-(naphthalen-1-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000396
-
-
 Homo sapiens N-(4-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.000042
-
-
 Homo sapiens N-benzyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000433
-
-
 Homo sapiens N-(2-phenylethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000445
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(2,4,6-tri-tert-butylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000469
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000491
-
-
 Homo sapiens N-(2,3-dihydro-1H-inden-2-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.00005
-
-
 Homo sapiens N-(4-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000521
-
-
 Homo sapiens 1-[(4-chloro-2,5-dimethylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
0.0000541
-
-
 Homo sapiens N-(2-chloro-4-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000591
-
-
 Homo sapiens N-(2,5-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.000064
-
-
 Homo sapiens N'-[2-(3-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
0.0000753
-
-
 Homo sapiens 4,5-dimethoxy-2-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate
0.0000876
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(2-fluorophenyl)sulfonyl]piperidine-4-carboxamide
0.0000911
-
-
 Homo sapiens 1-[(2-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
0.000128
-
-
 Homo sapiens N-(2,4-dichloro-6-methylbenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.00015
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-[(4-fluoro-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide
0.000164
-
-
 Homo sapiens 1-[(4-tert-butylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
0.000173
-
-
 Homo sapiens N-[4-chloro-3-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0002
-
-
 Homo sapiens 1-[(5-chlorothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
0.0002
-
-
 Homo sapiens 1,1'-(benzene-1,3-diyldicarbonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide]
0.0002
-
-
 Homo sapiens N-naphthalen-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0002
-
-
 Homo sapiens N-piperidin-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide