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Literature summary for 3.3.2.10 extracted from
- Mammalian epoxide hydrolases in xenobiotic metabolism and signalling (2009), Arch. Toxicol., 83, 297-318.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Homo sapiens |
| medicine | sEH is a target for the treatment of hypertension, inflammatory diseases, pain, diabetes, and stroke | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Homo sapiens |
| K55R | the sEH variant K55R has increased epoxide hydrolase activity and is associated with coronary artery disease | Mus musculus |
| R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Homo sapiens |
| R287Q | the R287Q mutation results in sEH protein with reduced stability and reduced epoxide hydrolase activity, as well as decreased ability of homodimer formation | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Homo sapiens | 5777 | - |
| peroxisome | in some cell types sEH shows a dual localisation, both cytosolic and peroxisomal | Mus musculus | 5777 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | P34914 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Mus musculus | - |
| ovary | - |
Homo sapiens | - |
| ovary | - |
Mus musculus | - |
| whole body | sEH is highly expressed throughout the body | Homo sapiens | - |
| whole body | sEH is highly expressed throughout the body | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Homo sapiens | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? |  |
| (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O | i.e. 8,9-EET | Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid | i.e. 8,9-DHET | ? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O | i.e. 14,15-EET | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid | i.e. 14,15-DHET | ? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Homo sapiens | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O | i.e. 11,12-EET | Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid | i.e. 11,12-DHET | ? | |
| (8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Homo sapiens | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
| (8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O | i.e. 5,6-EET | Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid | i.e. 5,6-DHET | ? | |
| hepoxilin A3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
| hepoxilin A3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
| hepoxilin B3 + H2O | excellent substrate for sEH | Homo sapiens | ? | - |
? | |
| hepoxilin B3 + H2O | excellent substrate for sEH | Mus musculus | ? | - |
? | |
| leukotoxin + H2O | - |
Homo sapiens | leukotoxin diol | - |
? | |
| leukotoxin + H2O | - |
Mus musculus | leukotoxin diol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
| homodimer | - |
Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EPHX2 | - |
Homo sapiens |
| EPHX2 | - |
Mus musculus |
| SEH | - |
Homo sapiens |
| SEH | - |
Mus musculus |
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Release 2023.1 (January 2023)
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