Literature summary for 3.3.2.10 extracted from

Seubert, J.M.; Sinal, C.J.; Graves, J.; DeGraff, L.M.; Bradbury, J.A.; Lee, C.R.; Goralski, K.; Carey, M.A.; Luria, A.; Newman, J.W.; Hammock, B.D.; Falck, J.R.; Roberts, H.; Rockman, H.A.; Murphy, E.; Zeldin, D.C.
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function (2006), Circ. Res., 99, 442-450.

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Application

Application	Comment	Organism
medicine	mice with targeted disruption of the Ephx2 gene coding for soluble epoxide hydrolase have normal heart anatomy and basal contractile function, but have higher fatty acid epoxide:diol ratios in plasma and cardiomyocytes cell culture media. The heart have improved recovery of left ventricular developed pressure and less infarction after 20 min ischemia, compared with wild-type. Perfusion with 14,15-epoxyeicosa-5(Z)-enoic acid before ischemia abolishes this cardioprotective phenotype. Enzyme null mice exhibit increased cardiac expression of glycogen synthase kinase-3beta phosphoprotein after ischemia	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	mice with targeted disruption of the Ephx2 gene coding for soluble epoxide hydrolase have normal heart anatomy and basal contractile function, but have higher fatty acid epoxide:diol ratios in plasma and cardiomyocytes cell culture media. The heart have improved recovery of left ventricular developed pressure and less infarction after 20 min ischemia, compared with wild-type. Perfusion with 14,15-epoxyeicosa-5(Z)-enoic acid before ischemia abolishes this cardioprotective phenotype. Enzyme null mice exhibit increased cardiac expression of glycogen synthase kinase-3beta phosphoprotein after ischemia	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

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Release 2023.1 (January 2023)