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Literature summary for 3.3.2.10 extracted from

  • Schmelzer, K.R.; Kubala, L.; Newman, J.W.; Kim, I.H.; Eiserich, J.P.; Hammock, B.D.
    Soluble epoxide hydrolase is a therapeutic target for acute inflammation (2005), Proc. Natl. Acad. Sci. USA, 102, 9772-9777.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
pharmacology the enzyme is a key target in treatment of acute systemic hypotension Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-adamantyl-3-(5-[2-(2-ethylethoxy)ethoxy]pentyl)urea i.e. compound 950 Mus musculus
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester i.e. AUDA-BE, physiologic consequences of enzyme inhibition in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme inhibition decreases plasma levels of proinflammatory cytokines and nitric oxide metabolites while promoting the formation of lipoxins, thus supporting inflammatory resolution ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C75BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-
plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme inhibition decreases plasma levels of proinflammatory cytokines and nitric oxide metabolites while promoting the formation of lipoxins, thus supporting inflammatory resolution Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus