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Literature summary for 3.3.2.10 extracted from

  • Sellers, K.W.; Sun, C.; Diez-Freire, C.; Waki, H.; Morisseau, C.; Falck, J.R.; Hammock, B.D.; Paton, J.F.; Raizada, M.K.
    Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat (2005), FASEB J., 19, 626-628.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
11-nonyloxy-undec-8-enoic acid i.e. 11-nonyloxy-undec-8-enoic acid Rattus norvegicus
AUDA i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid, inhibition in vivo by intracerebroventricular delivery Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
epoxyeicosatrienoic acid + H2O Rattus norvegicus physiological function and regulation of the reaction, overview dihydroxyeicosatrienoic acid
-
 ?
additional information Rattus norvegicus enzyme inhibition in vivo leads to increased blood pressure and heart rate due to an increase in epoxyeicosatrienoic acid-mediated generation of reactive oxygen species ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 spontaneously hypertensive, SHR, rats and Wistar Kyoto, WKY, rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain stem
-
 Rattus norvegicus
-
hypothalamus
-
 Rattus norvegicus
-
additional information enzyme expression is reduced in spontaneously hypertensive rats compared to normotensive rats Rattus norvegicus
-
neuron culture, from hypothalamus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epoxyeicosatrienoic acid + H2O
-
 Rattus norvegicus dihydroxyeicosatrienoic acid
-
 ?
epoxyeicosatrienoic acid + H2O physiological function and regulation of the reaction, overview Rattus norvegicus dihydroxyeicosatrienoic acid
-
 ?
additional information enzyme inhibition in vivo leads to increased blood pressure and heart rate due to an increase in epoxyeicosatrienoic acid-mediated generation of reactive oxygen species Rattus norvegicus ?
-
 ?