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Literature summary for 3.3.2.10 extracted from
- Rat and human liver cytosolic epoxide hydrolases: evidence for multiple forms at the level of protein and mRNA (1990), Environ. Health Perspect., 88, 49-55.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1-Benzylimidazole | activates mirosomal activity with styrene oxide as substrate | Homo sapiens |  |
| benzil | - |
Rattus norvegicus | |
| benzil | activates mirosomal activity with styrene oxide as substrate | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Benzylimidazole | microsomal activity with cis-stilbene oxide as substrate | Homo sapiens | |
| 1-trichloropropene oxide | - |
Homo sapiens | |
| benzil | inhibition of microsomal enzyme with cis-stilbene oxide, and of cytosolic enzyme forms cEHTSO and cEHCSO | Homo sapiens | |
| chalcone | microsomal activity with cis-stilbene oxide as substrate, cytosolic enzyme form cEHCSO and cEHTSO | Homo sapiens | |
| styrene oxide | - |
Homo sapiens | |
| styrene oxide | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0017 | - |
trans-stilbene oxide | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49000 | - |
x * 49000, SDS-PAGE | Homo sapiens |
| 49000 | - |
x * 49000, SDS-PAGE | Rattus norvegicus |
| 60000 | - |
2 * 60000, SDS-PAGE | Rattus norvegicus |
| 120000 | - |
gel filtration | Rattus norvegicus |
| 130000 | - |
gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
| 2 cytosolic enzyme forms: 1. cEHTSO, epoxide hydrolase with diagnostic substrate specificity for trans-stilbene oxide and 2. cEHCSO, epoxide hydrolase with diagnostic substrate specificity for cis-stilbene oxide | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cis-stilbene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
| cis-stilbene oxide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| styrene oxide + H2O | - |
Homo sapiens | styrene glycol | - |
? | |
| styrene oxide + H2O | - |
Rattus norvegicus | styrene glycol | - |
? | |
| trans-stilbene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
| trans-stilbene oxide + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 49000, SDS-PAGE | Homo sapiens |
| ? | x * 49000, SDS-PAGE | Rattus norvegicus |
| dimer | 2 * 60000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
cytosolic enzyme | Homo sapiens |
| 7.4 | - |
cytosolic enzyme | Rattus norvegicus |
| 9 | - |
- |
Rattus norvegicus |
| 9 | - |
microsomal enzyme | Homo sapiens |
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