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Literature summary for 3.3.2.10 extracted from
- Purification and characterization of an epoxide hydrolase from the peroxisomal fraction of mouse liver (1991), Arch. Biochem. Biophys., 285, 276-284.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4'-fluorochalcone oxide | - |
Mus musculus |  |
| 4'-methylchalcone oxide | - |
Mus musculus | |
| 4-benzyloxychalcone oxide | - |
Mus musculus | |
| 4-fluorochalcone oxide | - |
Mus musculus | |
| 4-methylchalcone oxide | - |
Mus musculus | |
| acetonitrile | 89% loss of activity at 5% acetonitrile | Mus musculus | |
| beta-naphthoflavone | - |
Mus musculus | |
| chalcone | - |
Mus musculus | |
| Chalcone oxide | - |
Mus musculus | |
| Clofibrate | 2 mM, 70-100% inhibition | Mus musculus | |
| ethanol | 3% inhibition at 3% ethanol | Mus musculus | |
| styrene oxide | - |
Mus musculus | |
| tetrahydrofuran | 73% loss of activity with 1% tetrahydrofuran, 98% loss of activity with 5% tetrahydrofuran | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0052 | - |
trans-stilbene oxide | cytosolic enzyme | Mus musculus | |
| 0.006 | - |
trans-stilbene oxide | peroxisomal enzyme | Mus musculus | |
| 0.027 | - |
cis-stilbene oxide | peroxisomal enzyme | Mus musculus | |
| 0.076 | - |
cis-stilbene oxide | cytosolic enzyme | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Mus musculus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
gel filtration | Mus musculus |
| 59000 | - |
1 * 59000, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.167 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cis-stilbene oxide + H2O | - |
Mus musculus | ? | - |
? | |
| trans-stilbene oxide + H2O | - |
Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 59000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TSO hydrolase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 51 | - |
- |
Mus musculus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 51 | 37°C: about 60% of maximal activity, 51°C: optimum | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
- |
Mus musculus |
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