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Literature summary for 3.2.2.9 extracted from

  • Allart, B.; Gatel, M.; Guillerm, D.; Guillerm, G.
    The catalytic mechanism of adenosylhomocysteine/methylthioadenosine nucleosidase from Escherichia coli (1998), Eur. J. Biochem., 256, 155-162.
    View publication on PubMed
Search for more literature for 3.2.2.9

Inhibitors

Inhibitors Comment Organism Structure
(5'R)-5'-deoxy-5'-methylthio-8,5'-cycloadenosine competitive inhibition Escherichia coli
2',3'-didehydromethylthioadenosine competitive inhibition Escherichia coli
3'-deoxy-methylthioadenosine competitive inhibition Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00083
-
 5'-methylthioadenosine
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-methylthioadenosine + H2O Escherichia coli
-
 ?
-
 ?
S-adenosyl-L-homocysteine + H2O Escherichia coli
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-2'-fluoro-5'-deoxy-5'-(methylthio)adenosine + H2O F-MeSAdo, slow substrate Escherichia coli adenine + ?
-
 ?
2'-deoxymethylthioadenosine + H2O fairly good substrate Escherichia coli adenine + 2-deoxymethylthioribose
-
 ?
5'-methylthioadenosine + H2O
-
 Escherichia coli 5-methylthio-D-ribose + adenine
-
 ?
5'-methylthioadenosine + H2O
-
 Escherichia coli ?
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli adenine + S-ribosyl-L-homocysteine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
(adoHcy)/methylthioadenosine nucleosidase
-
 Escherichia coli
adoHcy/MeSAdo nucleosidase
-
 Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5
-
 Escherichia coli