Cloned (Comment) | Organism |
---|---|
gene nga, cloning n Escherichia coli strain JM109, expression of wild-type and mutant enzymes | Streptococcus pyogenes M1 GAS |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the nga mutant of strain GT01 has lost all virulence | Streptococcus pyogenes M1 GAS |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein IFS | an endogenous NADase inhibitor, encoded by gene ifs, and localized in the cytoplasm. The NADase precursor exists as an inactive complex with IFS | Streptococcus pyogenes M1 GAS |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Streptococcus pyogenes M1 GAS | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes M1 GAS | - |
diverse strains, e.g. strain SF370, of low and high NADase activity, as isolates taken from streptococcal toxic shock-like syndrome, STSS, patients, gene nga | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
virulence/Mortality to mice of GAS isolates with different NADase activity, overview | Streptococcus pyogenes M1 GAS |
Synonyms | Comment | Organism |
---|---|---|
NAD-glycohydrolase | - |
Streptococcus pyogenes M1 GAS |
NADase | - |
Streptococcus pyogenes M1 GAS |
General Information | Comment | Organism |
---|---|---|
physiological function | NADase is important for the virulence of Streptococcus pyogenes in vivo, is important in severe invasive diseases, and is the potential target to suppress the virulence | Streptococcus pyogenes M1 GAS |