Protein Variants | Comment | Organism |
---|---|---|
additional information | derival of isogenic mutant strains deficient in expression of streptolysin O, the enzyme or both, more rapid internalization, as compared to the wild-type strain, into human keratinocytes, and reduced cytotoxicity and apoptosis occur, highly reduced enzyme content | Streptococcus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion | Streptococcus sp. | - |
- |
additional information | enzyme is incorporated into human host keratinocyte cytoplasm and membranes by aid of streptolysin O | Streptococcus sp. | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Streptococcus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + H2O | Streptococcus sp. | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | Streptococcus sp. 3 | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | ADP-ribose + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus sp. | - |
group A, e.g. virulent M-type 3 strain | - |
Streptococcus sp. 3 | - |
group A, e.g. virulent M-type 3 strain | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Streptococcus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + H2O | - |
Streptococcus sp. | ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | Streptococcus sp. | ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | - |
Streptococcus sp. 3 | ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | enzyme contributes to the pathogenicity of group A streptococci, after it is transported into the cytoplasm and membranes of host endothelial cells, by modulation of host cell signalling pathways to inhibit group A streptococci internalization, leading to apoptosis of keratinocytes | Streptococcus sp. 3 | ADP-ribose + nicotinamide | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Streptococcus sp. |
Synonyms | Comment | Organism |
---|---|---|
NAD+-glycohydrolase | - |
Streptococcus sp. |