Activating Compound | Comment | Organism | Structure |
---|---|---|---|
guanosine 5'-O-(3-thiotriphosphate) | enzyme may be regulated by a G protein-dependent mechanism | Mus musculus | |
additional information | increase in activity ba Triton X-100 treatment due to solubilization from the cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | about 80% inhibition at 1 mM | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
intracellular | - |
Mus musculus | 5622 | - |
membrane | no solubilization by phosphatidylinositol-specific phospholipase C or 0.5 M KCl, but by Triton X-100 | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + H2O | Mus musculus | - |
ADP-ribose + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
CD38-deficient strain, bifunctional enzyme, distinct from CD157 and CD38 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | CD38-deficient strain | Mus musculus | - |
nerve cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the ADP-ribosyl cyclase activity shows identical properties and is inseparable, thus the enzyme is bifunctional one | Mus musculus | ? | - |
? | |
NAD+ + H2O | - |
Mus musculus | ADP-ribose + nicotinamide | - |
? | |
NAD+ + H2O | low activity in CD38-deficient cell membranes at all developmental stages | Mus musculus | ADP-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyl cyclase/NAD+-glycohydrolase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
32 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
in presence of EDTA | Mus musculus |