Cloned (Comment) | Organism |
---|---|
expression in THP-1 cells, selection of transfected cells by G418 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
b-series gangliosides | - |
Homo sapiens | |
GD1a | exogenous ganglioside, slight inhibition, inhibition in vivo | Homo sapiens | |
GD1b | exogenous ganglioside, inhibition in vivo | Homo sapiens | |
GD3 | exogenous ganglioside, inhibition in vivo | Homo sapiens | |
GM1b | exogenous ganglioside, slight inhibition, inhibition in vivo | Homo sapiens | |
GT1b | exogenous ganglioside, inhibition in vivo, needs to be incorporated into the cell to inhibit CD38, preferably cis interaction, i.e. CD38 and GT1b are located on the same cell, the tandem sialic acid residues linked to the internal galactose of the gangliotetraose core are crucial to the inhibition | Homo sapiens | |
additional information | structure of the inhibiting gangliosides, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane protein with a catalytically active extracellular domain | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + H2O | Homo sapiens | - |
ADP-ribose + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
the extracellular domain of the leukocyte single transmembrane cell surface antigen CD38 shows NADase activity | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NAD+ + H2O = ADP-D-ribose + nicotinamide + H+ | the enzyme can also hydrolyse NADP+ to yield phospho-ADP-ribose and nicotinamide, but more slowly | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | leukemic cells, retinoic acid-treated | Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + H2O | - |
Homo sapiens | ADP-ribose + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD38 | - |
Homo sapiens |
NADase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |