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Literature summary for 3.2.2.31 extracted from

  • Woods, R.D.; OShea, V.L.; Chu, A.; Cao, S.; Richards, J.L.; Horvath, M.P.; David, S.S.
    Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases (2016), Nucleic Acids Res., 44, 801-810 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.31

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme bound to an azaribose transition state analog Geobacillus stearothermophilus

Protein Variants

Protein Variants Comment Organism
Y126F the mutant shows a 260fold slower rate of adenine removal compared to the wild type enzyme Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O Geobacillus stearothermophilus
-
 ?
-
 ?
DNA containing a guanine:adenine mismatch + H2O Geobacillus stearothermophilus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus P83847
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O
-
 Geobacillus stearothermophilus ?
-
 ?
DNA containing a guanine:adenine mismatch + H2O
-
 Geobacillus stearothermophilus ?
-
 ?

Synonyms

Synonyms Comment Organism
mutY
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 Geobacillus stearothermophilus