Any feedback?
Literature summary for 3.2.2.31 extracted from
- Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxide (2001), Mol. Genet. Genomics, 266, 336-342 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D172N | inactive | Schizosaccharomyces pombe |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | Schizosaccharomyces pombe | - |
? | - |
? |  |
| DNA containing a guanine:adenine mismatch + H2O | Schizosaccharomyces pombe | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatch + H2O | - |
Schizosaccharomyces pombe | ? | - |
? | |
| DNA containing a guanine:adenine mismatch + H2O | - |
Schizosaccharomyces pombe | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenine glycosylase | - |
Schizosaccharomyces pombe |
| MYH | - |
Schizosaccharomyces pombe |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | an enzyme-knockout strain displays a 36fold higher frequency of spontaneous mutations than the wild type strain. Enzyme gene disruption causes increased sensitivity to H2O2 but not UV irradiation | Schizosaccharomyces pombe |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
